ISSN: 2251-8363    eISSN: 2251-8819  
J Nephropathol. 2012;1(3):134-142.
doi:10.5812/nephropathol.8108
PMID: 24475404
PMCID: PMC3886144

Scopus id: 84874744640

Review Article

Dietary antioxidents and oxidative stress in predialysis chronic kidney disease patients

Krishan L Gupta 1 * , Nancy Sahni 2

1 Department of Dietetics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
2 Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
*Corresponding author: Krishan L Gupta, Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.Telephone:+91-172-(O) - 2100070 , Fax:+91-172-2749911/ 2744401, Email: klgupta@hotmail.com

Abstract

Context: Dietary antioxidants are important in protecting against human diseases. Oxidative stress, a non- traditional risk factors of cardio-vascular disease is far more prevalent in chronic kidney disease (CKD) patients than in normal subjects.

Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.

Results: Oxidative stress could be a consequence of an increase in reactive oxygen species as well as a decrease in antioxidant defenses. Among the important factors that can be involved in triggering oxidative stress is insufficient dietary intake of antioxidants. Malnourished CKD patients are reported to have more oxidative stress than well nourished ones.

Conclusions: Moving beyond the importance of assessment of dietary protein and energy in pre dialysis CKD patients to the assessment of dietary antioxidants is of utmost importance to help combat enhanced oxidative stress levels in such patients.

Implication for health policy/practice/research/medical education:

Oxidative stress is far more prevalent in chronic kidney disease (CKD) patients than in normal subjects. Malnourished CKD patients are reported to have more oxidative stress than well nourished ones. Moving beyond the importance of assessment of dietary protein and energy in pre dialysis CKD patients to the assessment of dietary antioxidants is of utmost importance to help combat enhanced oxidative stress levels in such patients. Unmonitored dietary restrictions and absence of nutritional intervention can be one of the reasons for low nutrient intake and poor antioxidant status of CKD patients.

Please cite this paper as: Sahni N, Gupta KL. Dietary antioxidents and oxidative stress in predialysis chronic kidney disease patients. J Nephropathology. 2012; 1(3): 134-142. DOI: 10.5812/nephropathol.8108

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First published online: 01 Oct 2012
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