ISSN: 2251-8363
eISSN: 2251-8819
Editorial Board
Aims and Scope
Current Issue
All Issues
Search
Sitemap
Rss
Contact Us
Indexes

Open Access

PubMed Central

PubMed

Scopus

DOI

ICMJE

WAME

Renal Pathology Society

publication ethics

CrossRef

CrossMark

CrossCheck

Journal of Nephropathology 2013;2(1):61-66. doi:10.5812/nephropathol.8940
Effects of N-acetyl cysteine on serum lipoprotein (a) and proteinuria in type 2 diabetic patients

Original Article

Hamid Rouhi * , Forouzan Ganji

Abstract

Background: About 30-40% of diabetic patients who developed nephropathy have lipoprotein disorders, especially lipoprotein a [Lp(a)], which is related to atherosclerosis.

Objectives: The aim of this study was to investigate the effect of N-acetyl cysteine (NAC) on the serum levels of Lp(a) and amount of proteinuria in a group of type 2 diabetic patients with diabetic nephropathy.

Patients and Methods: A total of 40, type 2 diabetic (T2D) patients, patients with proteinuria, were randomly divided into two groups. The experimental group was treated by NAC (1200 mg/day) for two months in conjunction with conventional treatment for diabetes and hypertension. Control group received routine medications.

Results: No significant change was identified in serum Lp(a) during treatment with NAC (P >0.05). However, NAC decreased the amount of proteinuria, serum triglyceride (TG) level and systolic blood pressure in experimental group compared to the control group (P <0.05).

Conclusions: These findings suggest that treatment with NAC has no significant effect on the serum level of Lp (a). However, it has beneficial effects on the reduction of proteinuria, serum TG level and systolic blood pressure in T2D patients with nephropathy. Further prospective studies are needed to determine its full role.



Key words
Diabetic nephropathy, Lipoprotein (a), N-acetyl cysteine (NAC)

Notes

Implication for health policy/practice/research/medical education:

This study was conducted to investigate the effect of N-acetyl cysteine (NAC) on the serum level of lipoprotein (a) [Lp (a)] and the amount of proteinuria in a group of type 2 diabetic patients .In this investigation, there were no significant changes in the serum Lp (a) during treatment with NAC. However, NAC decreased the amount of proteinuria, serum triglyceride level and systolic blood pressure in type 2 diabetic patients. These findings suggest that NAC may be useful in the treatment of proteinuria in these patients, although further prospective studies are needed to determine its full role.

Please cite this paper as: Rouhi H, Ganji F. Effects of N-acetyl cysteine on serum lipoprotein (a) and proteinuria in type 2 diabetic patients. J Nephropathology. 2013; 2(1): 61-66. DOI: 10.5812/nephropathol.8940


Comments
First name  
Last name  
Email address  
Comments  
Security code



Article
PDF
ePub

Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks

Cite by
Google Scholar
PubMed

Google Scholar
Articles by Hamid Rouhi
Articles by Forouzan Ganji
Similar articles
Related articles

PubMed
Articles by Hamid Rouhi
Articles by Forouzan Ganji


Article Access Statistics
Viewed
PDF Downloaded
Comments

Share this article!
Creative Commons Attribution 4.0 License This work is licensed under a Creative Commons Attribution 4.0 License.
Copyright © 2016 The Author(s)
Published by Society of Diabetic Nephropathy Prevention