Context: The extra-intestinal manifestations of inflammatory bowel disease (IBD) are
common and involve other organs or systems for example; urinary system.
Evidence Acquisitions: For this review, we used a variety of sources by searching through Web
of Science, PubMed, EMBASE, Scopus and directory of open access journals (DOAJ).
Results: Urinary complications may occur in up to 22% of patients and nephrolithiasis
or renal/kidney stones have been suggested to be a common manifestation of disease in
forms of uric acid, calcium phosphate or calcium oxalate. We performed a meta-analysis
on five clinical trials and reported that correlation between IBD and formation of stone in
renal system is positive and significant (Fix-effect model; CI: 95%, P <0.001, and randomeffect
model; CI: 95%, P = 0.03).
Conclusions: Based on the reports of the clinical trials, calcium oxalate is more prevalent in
Crohn’s disease (CD) than in ulcerative colitis (UC).