Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature

Mehri Mollaee; Tibor Fülöp; Sohil Abdul Salim; Mehrdad Hamrahian

doi:10.15171/jnp.2017.46

J Nephropathol. 2017;6(4): 278-281.
doi: 10.15171/jnp.2017.46

Scopus ID: 85036536499

Abstract View: 3525

PDF Download: 1638

Case Report

Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature

Mehri Mollaee ¹, Tibor Fülöp ², Sohil Abdul Salim ², Mehrdad Hamrahian ³^*

¹ Department of Pathology, Thomas Jefferson University; Philadelphia, PA, USA
² Department of Medicine - Nephrology, University of Mississippi; Jackson, MS, USA
³ Department of Medicine - Nephrology, Thomas Jefferson University; Philadelphia, PA, USA

*Corresponding Author: *Corresponding author: Mehrdad Hamrahian, , Email: seyed.hamrahian@jefferson.edu

Abstract

Background: Nodular glomerulosclerosis is a characteristic histological finding of diabetic
nephropathy (DN) with thickened glomerular basement membrane (GBM) and hyalinized
arterioles. Idiopathic nodular glomerulosclerosis (ING), a rare distinct clinicopathologic
entity, is the term used to denote classic DN confirmed by light microscopy, immunofluorescence,
and electron microscopy in the absence of diabetes mellitus (DM). ING
has been linked to heavy tobacco smoking, chronic hypertension, obesity and insulin
resistance. Its association with marijuana use is unknown.

Case Presentation: We report a case of biopsy-proved ING in the absence of pre-existing
history of DM and heavy smoking. This report addresses the possible accentuation of
tobacco use risk by marijuana.

Conclusions: This report addresses the possible accentuation of tobacco use risk by marijuana.

Keywords: Idiopathic nodular glomerulosclerosis, Marijuana, Proteinuria, Smoking

Implication for health policy/practice/research/medical education:

Idiopathic nodular glomerulosclerosis (ING) is a rare distinct clinicopathologic entity that has been linked to heavy tobacco smoking, chronic hypertension, obesity and insulin resistance. Its association with marijuana use is unknown. We report a case of biopsy-proved ING in the absence of pre-existing history of diabetic nephropathy (DN) and heavy smoking. This report addresses the possible accentuation of tobacco use risk by marijuana.

Please cite this paper as: Mollaee M, Fülöp T, Abdul Salim S, Hamrahian M. Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature. J Nephropathol. 2017;6(4):278-281. DOI: 10.15171/jnp.2017.46.

First Name

Last Name

Email Address

Comments

Security code

Generate New Image

Type the code from the image

Abstract View: 3526

years	Jan	Feb	Mar	Apr	May	Jun	Jul	Aug	Sep	Oct	Nov	Dec
2024	17	14	19	9	15	18	15	32	27	37	23
2023	43	40	37	22	3	33	20	29	26	47	54	31
2022	78	89	92	93	48	61	57	36	23	33	41	57
2021	39	40	31	44	41	46	36	44	46	44	55	48
2020	42	27	42	50	50	41	61	136	110	59	44	40
2019	42	32	33	40	42	33	33	36	38	28	25	31
2018	77	52	64	50	34	27	23	24	37	27	32	36
2017											5	90

PDF Download: 1638

years	Jan	Feb	Mar	Apr	May	Jun	Jul	Aug	Sep	Oct	Nov	Dec
2024	3	11	11	6	9	11	7	14	15	21	10
2023	23	13	12	12		14	11	25	11	10	9	17
2022	10	18	13	12	16	10	12	12	11	9	18	11
2021	17	18	13	14	24	19	24	31	35	18	35	21
2020	19	13	15	19	13	15	26	18	22	20	18	21
2019	47	29	29	26	31	19	24	20	18	17	15	23
2018	73	32	37	28	19	21	16	15	19	18	23	30
2017											6	88