Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature

Mehri Mollaee; Tibor Fülöp; Sohil Abdul Salim; Mehrdad Hamrahian

doi:10.15171/jnp.2017.46

J Nephropathol. 2017;6(4): 278-281.
doi: 10.15171/jnp.2017.46

Scopus ID: 85036536499

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Case Report

Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature

Mehri Mollaee ¹, Tibor Fülöp ², Sohil Abdul Salim ², Mehrdad Hamrahian ³^*

¹ Department of Pathology, Thomas Jefferson University; Philadelphia, PA, USA
² Department of Medicine - Nephrology, University of Mississippi; Jackson, MS, USA
³ Department of Medicine - Nephrology, Thomas Jefferson University; Philadelphia, PA, USA

*Corresponding Author: *Corresponding author: Mehrdad Hamrahian, , Email: seyed.hamrahian@jefferson.edu

Abstract

Background: Nodular glomerulosclerosis is a characteristic histological finding of diabetic
nephropathy (DN) with thickened glomerular basement membrane (GBM) and hyalinized
arterioles. Idiopathic nodular glomerulosclerosis (ING), a rare distinct clinicopathologic
entity, is the term used to denote classic DN confirmed by light microscopy, immunofluorescence,
and electron microscopy in the absence of diabetes mellitus (DM). ING
has been linked to heavy tobacco smoking, chronic hypertension, obesity and insulin
resistance. Its association with marijuana use is unknown.

Case Presentation: We report a case of biopsy-proved ING in the absence of pre-existing
history of DM and heavy smoking. This report addresses the possible accentuation of
tobacco use risk by marijuana.

Conclusions: This report addresses the possible accentuation of tobacco use risk by marijuana.

Keywords: Idiopathic nodular glomerulosclerosis, Marijuana, Proteinuria, Smoking

Implication for health policy/practice/research/medical education:

Idiopathic nodular glomerulosclerosis (ING) is a rare distinct clinicopathologic entity that has been linked to heavy tobacco smoking, chronic hypertension, obesity and insulin resistance. Its association with marijuana use is unknown. We report a case of biopsy-proved ING in the absence of pre-existing history of diabetic nephropathy (DN) and heavy smoking. This report addresses the possible accentuation of tobacco use risk by marijuana.

Please cite this paper as: Mollaee M, Fülöp T, Abdul Salim S, Hamrahian M. Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature. J Nephropathol. 2017;6(4):278-281. DOI: 10.15171/jnp.2017.46.

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Abstract View: 3559

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