Background: Unilateral ureteral obstruction (UUO) alters the expression of renin-angiotensin
system (RAS) components and angiotensin II (Ang II) as the main arm of RAS is affected
Objectives: In this study the role of Ang II subtypes 1 and 2 receptors (AT1R and AT2R)
antagonists (losartan and PD123319) was examined in renal hemodynamic responses to
graded Ang II infusion in sham, 3-day UUO and removal UUO (RUUO) models in rats.
Materials and Methods: Seventy-one male Wistar rats randomly divided into three different
sets of animal models; sham-operated, UUO and RUUO that each set contains three groups
treated with vehicle, losartan, and PD123319. Renal vascular responses to Ang II infusion
were measured at controlled renal perfusion pressure (RPP).
Results: The graded Ang II infusion decreased renal blood flow (RBF), increased renal
vascular resistance (RVR) and mean arterial pressure (MAP) in vehicle or PD123319 treated
groups significantly (P<0.005), but no significant difference was found between these
treated groups. However, RBF, RVR and MAP responses to graded Ang II infusion in
losartan-treated rats were attenuated significantly when compared with vehicle or PD123319
treated groups (P<0.05). In addition, the RBF, RVR and MAP responses to Ang II were not
similar in sham, UUO and RUUO rats treated with losartan.
Conclusions: Vascular responses to Ang II in UUO and RUUO rat model treated with losartan
is not as the normal pattern.