ISSN: 2251-8363    eISSN: 2251-8819  
J Nephropathol. 2018;7(2):57-64.
doi:10.15171/jnp.2018.15

Original Article

Renal blood flow and vascular resistance responses to angiotensin II in irreversible and reversible unilateral ureteral obstruction rats; the role of angiotensin II type 1 & 2 receptors

Jalal Hassanshahi 1,2, Maryam Maleki 3, Mehdi Nematbakhsh 1,2,4 *

1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Physiology, Ilam University of Medical Sciences, Ilam, Iran
4 IsfahanMN Institute of Basic & Applied Sciences Research, Isfahan, Iran

Abstract

Background: Unilateral ureteral obstruction (UUO) alters the expression of renin-angiotensin system (RAS) components and angiotensin II (Ang II) as the main arm of RAS is affected by UUO.

Objectives: In this study the role of Ang II subtypes 1 and 2 receptors (AT1R and AT2R) antagonists (losartan and PD123319) was examined in renal hemodynamic responses to graded Ang II infusion in sham, 3-day UUO and removal UUO (RUUO) models in rats.

Materials and Methods: Seventy-one male Wistar rats randomly divided into three different sets of animal models; sham-operated, UUO and RUUO that each set contains three groups treated with vehicle, losartan, and PD123319. Renal vascular responses to Ang II infusion were measured at controlled renal perfusion pressure (RPP).

Results: The graded Ang II infusion decreased renal blood flow (RBF), increased renal vascular resistance (RVR) and mean arterial pressure (MAP) in vehicle or PD123319 treated groups significantly (P<0.005), but no significant difference was found between these treated groups. However, RBF, RVR and MAP responses to graded Ang II infusion in losartan-treated rats were attenuated significantly when compared with vehicle or PD123319 treated groups (P<0.05). In addition, the RBF, RVR and MAP responses to Ang II were not similar in sham, UUO and RUUO rats treated with losartan.

Conclusions: Vascular responses to Ang II in UUO and RUUO rat model treated with losartan is not as the normal pattern.

Implication for health policy/practice/research/medical education:

The expression of renin-angiotensin system (RAS) components alters in UUO model and AngII as the main arm of RAS is affected by unilateral ureteral obstruction (UUO). From the findings of the present study, we can conclude that the vascular responses to Ang II in losartan treated rats are not as the normal pattern in both UUO and removal UUO (RUUO) models.

Please cite this paper as: Hassanshahi J, Maleki M, Nematbakhsh M. Renal blood flow and vascular resistance responses to angiotensin II in irreversible and reversible unilateral ureteral obstruction rats; the role of angiotensin II type 1 & 2 receptors. J Nephropathol. 2018;7(2):57-64. DOI: 10.15171/jnp.2018.15.

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Submitted: 02 May 2017

Accepted: 09 Oct 2017
First published online: 27 Oct 2017
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