ISSN: 2251-8363    eISSN: 2251-8819  
J Nephropathol. 2018;7(1):25-31.
doi:10.15171/jnp.2018.09

Scopus id: 85041138589

Review

Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis

Ali Hasanpour Dehkordi 1,2, Majid Dousti 3, Faezeh Kiani 3, Mona Zamanian Azodi 4 * , Mostafa RezaeiTavirani 4, Kourosh Sayehmir 5

1 Social determinants of Health Research Center, Shahrekord University of Medical sciences, Shahrekord, Iran
2 Department of Medical-Surgical, Faculty of Nursing and Midwifery, Shahrekord University of Medical sciences, Shahrekord, Iran
3 Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
4 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Department of Biostatistics, Psychosocial Injury Research Center, Ilam University of Medical Sciences, Ilam, Iran
*Corresponding author: Mona Zamanian Azodi, Email: mona.azodi@gmail.com

Abstract

Context: Type 2 diabetes mellitus (T2DM) is a multi-factorial disease with several genetic and environmental factors known to be associated with the disease. Tumor necrosis factoralpha (TNF-α) acts on fat cells associated with increased insulin resistance and obesity and its increase can be associated with the prevalence of T2DM. Previous studies on the relationship between 308 G/A polymorphism in TNF-α and T2DM were not conclusive. The aim of this study was to investigate the association between 308 G/A polymorphism in TNF-α gene and T2DM using a systematic review and meta-analysis. Evidence Acquisitions: In this systematic review we searched all published studies about the association between TNF 308 G/A polymorphism and T2DM through databases such as Scopus, Science direct, PubMed and Google scholar. A fixed or random effect model was used on the basis of heterogeneity. The heterogeneity was assessed using the I2 index. We used STATA software (version 11.2) for data analysis.

Results: In 22 selected papers, the total number of T2DM and control subject was 8485 and 8615, respectively. Odds ratios (ORs) with 95% confidence intervals(CI) for the GG genotype polymorphism 308 G/A in total, Asian populations and whites (Caucasian) were estimated as OR=0.98 (95% CI: 0.96-1.00), OR=0.96 (95% CI: 0.93 to 0.99) and OR=1.00 (95% CI: 0.97 to 1.40). The Publication Bias/or heterogeneity was observed in this study.

Conclusions: The present investigation have shown that 308 G/A polymorphism GG and GA genotypes in TNF-α gene cannot be considered as predictors of T2DM (P<0.05).

Implication for health policy/practice/research/medical education:

In a systematic review on 22 selected papers, we found that 308 G/A polymorphism GG and GA genotypes in TNF-α gene cannot be considered as predictors of type 2 diabetes mellitus (P<0.05).

Please cite this paper as: Hasanpour Dehkordi A, Dousti M, Kiani F, Zamanian Azodi M, Rezaei-Tavirani M, Sayehmiri K. Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis. J Nephropathol. 2018;7(1):25-31. DOI: 10.15171/jnp.2018.09.

First name
 
Last name
 
Email address
 
Comments
 
Security code


Submitted: 15 Jul 2017

Accepted: 17 Dec 2017
First published online: 05 Jan 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

Abstract Page Views: 692
PDF Downloads: 570
Full Text Views: 0