ISSN: 2251-8363    eISSN: 2251-8819  
J Nephropathol. 2018;7(1):32-36.
doi:10.15171/jnp.2018.10

Scopus id: 85041115506

Original Article

The relationship between serum ghrelin levels and bone metabolism markers and severity anemia in non-diabetic hemodialysis patients; a pilot study

Leila Mahmoodnia 1, Sara Beigrezaei 2, Mohammad Reza Tamadon 3, Tina Jafari 4, Marzieh Kafeshani 5, Fatemeh Mahmoodi 1, Ali Hasanpour Dehkordi 6, Masoud Amiri 7 *

1 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran
4 Department of Biochemistry and Nutrition, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord
5 Food Security Research Center and Department of Clinical Nutrition/Community Nutrition/Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
6 Social determinants of Health Research Center/Department of Medical-Surgical, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran
7 Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Masoud Amiri Ph.D, Email: masoud.amiri@yahoo.com

Abstract

Background: Chronic kidney disease (CKD) is a consequence of progressive and irreversible destruction of nephrons, mainly due to uncontrolled diabetes mellitus and high blood pressure. Ghrelin is a peptide hormone which could play a substantial role in hunger sensation, may increase body fat percentage and might adjust the long-term body weight and is mostly secreted in the stomach.

Objectives: This study aimed to evaluate the relationship between ghrelin levels and various biochemical and demographic indices in a group of non-diabetic hemodialysis patients.

Patients and Methods: Around 39 non-diabetic patients undergoing hemodialysis in Hajar hospital at Shahrekord city were enrolled. Results: The mean age of patients was 57.10±20.20 years. Their mean weight was 56.65 ±16.25 kg. Their hemoglobin level mean was 10.43±1.84 g/dL. The serum ghrelin level had a positive but not significant correlation with the age, dialysis quality, dosage, calcium level, alkaline phosphatase (ALP), parathormone, vitamin D and hemoglobin in these patients.

Conclusions: More studies in this subject of hemodialysis patients to define the exact role of ghrelin in hemodialysis patients are recommended.

Implication for health policy/practice/research/medical education:

In a study on 39 non-diabetic patients undergoing hemodialysis, we found that serum ghrelin level had a positive but not significant correlation with the age, dialysis quality, dosage, calcium level, alkaline phosphatase (ALP), parathormone, vitamin D and hemoglobin in these patients.

Please cite this paper as: Mahmoodnia L, Beigrezaei S, Tamadon MR, Jafari T, Kafeshani M, Mahmoodi F, et al. The relationship between serum ghrelin levels and bone metabolism markers and severity anemia in non-diabetic hemodialysis patients; a pilot study. J Nephropathol. 2018;7(1):32-36. DOI: 10.15171/jnp.2017.10.

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