Implication for health policy/practice/research/medical education:
Chronic complications of diabetes mellitus are directly related to high blood glucose levels.
Increasing blood glucose results in non-enzymatic glucose binding to proteins inside and
outside the cell. Several biochemical and molecular factors such as increased blood glucose,
oxidative stress, increased concentrations of ultimate glycosylated products, inflammation
can affect nephropathy. Metformin is another treatment for diabetes which mainly used
as the first treatment in patients with type 2 diabetes (T2D). Insulin is a peptide hormone
produced by pancreatic beta cells and plays a major role in regulating carbohydrate and fat
metabolism in the body.
Please cite this paper as: Babaeenezhad E, Hasanvand A. Renoprotective impacts of metformin
with insulin in type 1 diabetes; role of its antioxidant efficacy. J Nephropathol. 2018;7(3):217-
219. DOI: 10.15171/jnp.2018.45.