ISSN: 2251-8363    eISSN: 2251-8819  
J Nephropathol. 2018;7(3):217-219.
doi:10.15171/jnp.2018.45

Commentary

Renoprotective impacts of metformin with insulin in type 1 diabetes; role of its antioxidant efficacy

Esmaeel Babaeenezhad 1, Amin Hasanvand 2 *

1 Student of Veterinary Medicine, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
2 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
*Corresponding author: Amin Hasanvand, Ph.D.; Email: Email: dr.hasanvand@yahoo.com

Implication for health policy/practice/research/medical education:

Chronic complications of diabetes mellitus are directly related to high blood glucose levels. Increasing blood glucose results in non-enzymatic glucose binding to proteins inside and outside the cell. Several biochemical and molecular factors such as increased blood glucose, oxidative stress, increased concentrations of ultimate glycosylated products, inflammation can affect nephropathy. Metformin is another treatment for diabetes which mainly used as the first treatment in patients with type 2 diabetes (T2D). Insulin is a peptide hormone produced by pancreatic beta cells and plays a major role in regulating carbohydrate and fat metabolism in the body.

Please cite this paper as: Babaeenezhad E, Hasanvand A. Renoprotective impacts of metformin with insulin in type 1 diabetes; role of its antioxidant efficacy. J Nephropathol. 2018;7(3):217- 219. DOI: 10.15171/jnp.2018.45.

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Submitted: 10 Apr 2018

Accepted: 18 May 2018
First published online: 03 Jun 2018
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