J Nephropathol. 2019;8(1):4-4.
doi: 10.15171/jnp.2019.04
  Abstract View: 121
  PDF Download: 117

Original Article

Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity

Sayyedehnikta Kasae 1,2, Saeid Keshavarz 3, Bahar Mazaheri 2, Behzad Zolfaghari 4, Ardeshir Talebi 2, Mehdi Nematbakhsh 2,5,6 *

1 Department of Physical Education and Sport Sciences, Najaf-Abad Branch, Islamic Azad University, Najaf-Abad, Isfahan, Iran
2 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Sport Medicine Research Center, Najaf-Abad Branch, Islamic Azad University, Najaf-Abad, Isfahan, Iran
4 Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
6 IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran
*Corresponding author: Prof. Mehdi Nematbakhsh, Ph.D, Email; Email: nematbakhsh@mui.ac.ir

Abstract

Background: Nephrotoxicity is the cisplatin therapy side effect due to stress oxidative formation and lack of antioxidants.

Objectives: The role of aerobic exercise and three different doses of unripe grape extract as an antioxidant on cisplatin-induced nephrotoxicity were studied

Materials and Method: Seventy male Wistar rats were randomly divided into groups of control, cisplatin (2.5 mg/kg/d for 7 days), aerobic exercise + cisplatin and unripe grape extract and also aerobic exercise + unripe grape extract. Aerobic exercise was administered in period of 7 weeks (5 days/week, 1 h/d), and unripe grape extract was used in three different doses of 20, 100, 200 mg/ kg/d for period of 7 weeks.

Results: Cisplatin elevated the serum levels of blood urea nitrogen (BUN), creatinine and malondialdehyde (MDA), and also kidney weight and kidney tissue damage score and decreased body weight and the kidney tissue levels of nitrite significantly (P<0.05), but aerobic exercise or unripe grape extract did not alter the parameters toward normal levels.

Conclusions: Based on these findings, aerobic exercise and antioxidant such as unripe grape extract may not protect the kidney against cisplatin-induced nephrotoxicity during anti-cancer therapy

Implication for health policy/practice/research/medical education:

To avoid using aerobatic exercise and unripe grape as antioxidants to expect the prevention of cisplain induced nephrotoxicity.

Please cite this paper as: Kasaei S, Keshavarz S, Mazaheri B, Zolfaghari B, Talebi A, Nematbakhsh M. Aerobic exercise and unripe grape extract as antioxidant do not protect the kidney against cisplatin induced nephrotoxicity. J Nephropathol. 2019;8(1):e04. DOI: 10.15171/jnp.2019.04.

First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 121

Your browser does not support the canvas element.


PDF Downloaded: 117

Your browser does not support the canvas element.

Submitted: 03 Mar 2018
Accepted: 14 Jul 2018
First published online: 10 Aug 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)