J Nephropathol. 2019;8(1):9-9.
doi: 10.15171/jnp.2019.09
  Abstract View: 121
  PDF Download: 109

Original Article

Impact of fibroblast growth factor-23 on blood pressure and pulse pressure in hemodialysis patients; a multicenter study

Farzanehsadat , Minoo 1,2, Mahdieh Jamshidi 3, Elham Ramezanzadeh 4 * , Mohammadtaghi Najafi 1,2, Azam Alamdari 1,2

1 Nephrology Research Center, Tehran University of Medical Science, Tehran, Iran
2 Center of Excellence in Nephrology, Tehran University of Medical Science, Tehran, Iran
3 Nephrology Department, Rafsanjan University of Medical Science, Rafsanjan, Iran
4 Organ Transplantation Research Center, School of Medicine, Guilan University of Medical Science, Rasht, Iran
*Corresponding author: Elham Ramezanzadeh: Email: Email: rz.elham58@gmail.com

Abstract

Introduction: Hypertension seems to be a major problem in dialysis patients. Fibroblast growth factor-23 (FGF-23) appears to be a risk factor for mortality in patients with end-stage renal disease (ESRD).

Objectives: This study aims to investigate FGF-23 and its association with blood pressure and pulse pressure among hemodialysis patients.

Patients and Methods: This cross-sectional multicenter study was performed on 135 patients aged 18 years and over with ESRD treated with hemodialysis. Systolic and diastolic blood pressure of all patients was measured. FGF-23, uric acid, Na and K were measured using blood test and fasting. We used univariate and multivariate linear and non-linear regression.

Results: The mean age of patients was 56.45±13.64 years. Around 60% of patients were male. The mean and median FGF-23 in patients was 855.07±43.33 pg/mL and 762.6 pg/mL (IQR=456.6-1430.3) respectively. After adjustment for age, gender, dialysis time, uric acid, Na, K and kt/V, FGF-23 had quadratic association with pulse pressure. We found, each 10-unit (pg/mL) increase in FGF-23 was significantly associated with 0.50 mm Hg decrease in minimum pulse pressure (P=0.002) and 0.42 mm Hg decrease in mean pulse pressure (P= 0.009).

Conclusions: FGF23 had a significant association with dialysis vintage and a significant reverse association with minimum and mean pulse pressure.

Implication for health policy/practice/research/medical education:

In this study we aimed to assess correlation between fibroblast growth factor-23 and pulse pressure and blood pressure in hemodialysis patients. FGF-23 had a significant reverse association with minimum pulse pressure and mean pulse pressure.

Please cite this paper as: Minoo F, Jamshidi M, Ramezanzadeh E, Najafi M, Alamdari A. Impact of fibroblast growth factor-23 on blood pressure and pulse pressure in hemodialysis patients; a multicenter study. J Nephropathol. 2019;8(1):e09. doi: 10.15171/jnp.2019.09.

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Submitted: 25 Jun 2018
Accepted: 08 Nov 2018
First published online: 06 Dec 2018
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