Inhibition of gentamicin–induced renal tubular cell necrosis

Majid Tavafi

doi:10.5812/nephropathol.7512

J Nephropathol. 2012;1(2):83-86.
doi: 10.5812/nephropathol.7512

PMID: 24475394
PMCID: PMC3886137
Scopus id: 84874863773

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Commentary

Inhibition of gentamicin–induced renal tubular cell necrosis

Majid Tavafi ¹ *

¹ Department of Anatomy, Faculty of Medicine, Lorestan University of Medical Sciences, Khoram Abad Iran.

*Corresponding author: Majid Tavafi , Department of Anatomy, Faculty of Medicine, Lorestan University of Medical Sciences, Khoram Abad, Iran. Telephone: 00989188527146, Fax: 00989188527146 Email: mail tavafi.m@lums.ac.ir

Abstract

Gentamicin nephrotoxicity limit its usage against gram negative bacteria. Most researches showed that antioxidant agents improved gentamicin nephrotoxicity. According to these investigations oxidative stress play a central role in the mechanism of gentamicin induced nephrotoxicity. Recently Rafieian-Kopaei and colleagues showed that erythropoietin significantly ameliorated serum creatinine, blood urea nitrogen and tubal necrosis in gentamicin induced nephrotoxicity in rat. One of the advantages of this study is treatment of rats for 10 days by erythropoietin after inducing gentamicin nephrotoxicity and besides co- treatment of gentamicin and erythropoietin at 10 days simultaneously. They showed that erythropoietin improved significantly serum creatinine and blood urea nitrogen in gentamicin injected rats simultaneously and even after gentamicin nephrotoxicity induction. This study also showed that erythropoietin ameliorates histopathological injuries especially tubular cell necrosis that induced by gentamicin. Although the detailed renoprotective mechanisms of erythropoietin cannot be fully explained by this study but histological and biochemical results are satisfactory.

Keywords: Erythropoietin, Gentamicin, Nephrotoxicity

Implication for health policy/practice/research/medical education:

Most researches against gentamicin nephrotoxicity focused on the use of various antioxidants. In the recent study Rafieian-Kopaei et al. investigate the effect of erythropoietin in inhibition of gentamicin nephrotoxicity. They showed that erythropoietin improved significantly serum creatinine , blood urea nitrogen and histopathological injuries especially tubular cell necrosis in gentamicin injected rats simultaneously and even after gentamicin nephrotoxicity induction. Although the detailed renoprotective mechanisms of erythropoietin cannot be fully explained by this study but histological and biochemical results are satisfactory.

Please cite this paper as: Tavafi M. Inhibition of gentamicin – induced renal tubular cell necrosis. J Nephropathology. 2012; 1(2): 83-86. DOI: 10.5812/nephropathol.7512

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