Implication for health policy/practice/research/medical education:
Most researches against gentamicin nephrotoxicity focused on the use of various antioxidants. In the recent study Rafieian-Kopaei et al. investigate the effect of erythropoietin in inhibition of gentamicin nephrotoxicity. They showed that erythropoietin improved significantly serum creatinine , blood urea nitrogen and histopathological injuries especially tubular cell necrosis in gentamicin injected rats simultaneously and even after gentamicin nephrotoxicity induction. Although the detailed renoprotective mechanisms of erythropoietin cannot be fully explained by this study but histological and biochemical results are satisfactory.
Please cite this paper as: Tavafi M. Inhibition of gentamicin – induced renal tubular cell necrosis. J Nephropathology. 2012; 1(2): 83-86. DOI: 10.5812/nephropathol.7512