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J Nephropathol. 2012;1(3): 160-161.
doi: 10.5812/nephropathol.8112
PMID: 24475408
PMCID: PMC3886154
Scopus ID: 84924933843
  Abstract View: 1884
  PDF Download: 768

Commentary

The significance of HLA typing in transplantation

Shirin Farjadian 1 *

1 Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
*Corresponding author: Dr.Shirin Farjadian, Department of Immunology, Shiraz University of Medical Sciences. Shiraz, Iran. Tel/Fax: +98 711 2351575. farjadsh@sums.ac.ir

Abstract

Although genetic admixture has recently occurred among different ethnic groups with the increased rates of migration to big cities, information about HLA allele distribution in different ethnic groups in Iran may still be helpful to improve the selection of transplantation donor candidates from certain ethnic groups which are genetically closer to the recipient. Because the data reported by Einollahi et al. reflect a large HLA disparity among Iranian kidney recipients, any improvement could play a small yet important role in organ transplantation.
Keywords: HLA molecules, Graft rejection, Organ transplantation

Implication for health policy/practice/research/medical education:

To reduce the risk of allograft rejection, transplantation from HLA-matched donors is recommended. Due to the high cost of HLA typing, limiting the number of donors based on genetic distances among ethnic groups is potentially useful. Anthropological data may help to choose better donor candidates from ethnic groups which are genetically closer to the recipient.

Please cite this paper as: Farjadian S. The significance of HLA typing in transplantation. J Nephropathology. 2012; 1(3): 160-161. DOI: 10.5812/nephropathol.8112

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ePublished: 01 Oct 2012
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