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J Nephropathol. 2013;2(4): 217-233.
doi: 10.12860/JNP.2013.36
PMID: 24475454
PMCID: PMC3891131
Scopus ID: 84894086553
  Abstract View: 1876
  PDF Download: 943

Review Article

Hepatitis C virus infection in nephrology patients

Lionel Rostaing 1,2,3 * , Jacques Izopet 2,3,4, Nassim Kamar 1,2,3
*Corresponding author:Prof. Lionel Rostaing, Department of Nephrology, Dialysis, and Organ Transplantation CHU Rangueil, Toulouse University Hospital.1Avenue J.Poulhès, TSA 50032, 31059 Toulouse Cedex 9, France. Tel: + 33 5 61 32 25 84, Fax: + 33 5 61 32 28 64, rostaing.l@chu-toulouse.fr

Abstract

Context: Hepatitis C virus (HCV) infection leads to chronic liver disease, but also to extra-hepatic manifestations.

Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.

Results: Herein, we provide an overview of renal diseases related to HCV and their therapies, as well as the treatment options available for HCV (+)/RNA (+) dialysis patients. We will not mention, however, HCV infection-related complications in the post-kidney transplantation setting.

Conclusions: Extra-hepatic manifestations of HCV infection include mixed cryoglobulinemia, lymphoproliferative disorders, and renal disease. HCV infection has been reported in association with distinct histological patterns of glomerulonephritis in native kidneys.

Keywords: Hepatitis C, Glomerulonephritis, Renal transplantation, Membranoproliferative glomerulonephritis

Implication for health policy/practice/research/medical education:

Hepatitis C virus (HCV) infection leads to chronic liver disease, but also to extra-hepatic manifestations. These include mixed cryoglobulinemia, lymphoproliferative disorders, and renal disease. HCV infection has been reported in association with distinct histological patterns of glomerulonephritis in native kidneys . Membranoproliferative glomerulonephritis (MPGN) associated with type II cryoglobulinemia is the predominant type of HCV-related glomerulonephritis.

Please cite this paper as: Rostaing L, Izopet J, Kamar N. Hepatitis C virus infection in nephrology patients. J nephropathology. 2013; 2(4): 217-233, DOI: 10.12860/JNP.2013.36

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ePublished: 01 Jul 2013
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