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J Nephropathol. 2013;2(4): 234-240.
doi: 10.12860/JNP.2013.37
PMID: 24475455
PMCID: PMC3891126
Scopus ID: 84877997343
  Abstract View: 1871
  PDF Download: 1058

Review Article

A story of microalbuminuria and diabetic nephropathy

Bijan Roshan 1 * , Robert C. Stanton 2
*Corresponding author:Dr. BijanRoshan, MD, FASN1 Division of Renal Diseases and Hypertension, University of Colorado Denver, 12700 East 19th Ave. Room 7015Aurora, CO 80045, USA. bijan.roshan@ucdenver.edu

Abstract

Context: It is estimated that more than 346 million people worldwide have diabetes mellitus . By the year 2030, it is predicted that diabetes will become the seventh leading cause of death in the world. Development of chronic kidney disease (CKD) in patients with diabetes adds significantly to the morbidity and mortality and significantly increases health care costs, even before the development of end stage renal disease (ESRD).

Evidence  acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.

Results: Diabetic nephropathy (DN) is increasing rapidly worldwide. It is the leading cause of new cases of ESRD in the USA.  Interestingly, although DN is the most common cause of ESRD in diabetic patients, diabetes mellitus is also an independent and strong risk factor for ESRD ascribed to causes other than DN (e.g. hypertensive nephropathy).

Conclusions: It is important to be aware of the pitfalls of using the urine albumin level in predicting development and progression of diabetic nephropathy in order to treat and advise the patients accurately.  Research into finding new markers is rapidly evolving but current progress makes it likely we will be using the urine albumin level for some years into the future.

Keywords: Microalbuminuria, Diabetic nephropathy, Chronic kidney disease

Implication for health policy/practice/research/medical education:

It is important to be aware of the pitfalls of using the urine albumin level in predicting development and progression of diabetic nephropathy in order to treat and advise the patients accurately. Research into finding new markers is rapidly evolving but current progress makes it likely we will be using the urine albumin level for some years into the future.

Please cite this paper as: Roshan B, Stanton RC. A story of microalbuminuria and diabetic nephropathy. J Nephropathology. 2013; 2(4): 234-240, DOI: 10.12860/JNP.2013.37

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ePublished: 01 Oct 2013
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