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J Nephropathol. 2013;2(4): 249-253.
doi: 10.12860/JNP.2013.39
PMID: 24475457
PMCID: PMC3891128
Scopus ID: 84881179051
  Abstract View: 1911
  PDF Download: 1001

Original Article

Evaluation of noninvasive tests for diagnosis of Helicobacterpylori infection in hemodialysis patients

Mohamad Reza Tamadon 1 * , Morteza Saberi Far 1, Alireza Soleimani 2, Raheb Ghorbani 3, Vahid Semnani 4, Farhad Malek 5, Mojtaba Malek 6
*Corresponding author:Dr. MojtabaMalek, Endocrine Research Center (Firouzgar), Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran. Tel: +98 912 131 3538, Fax: +98 231 3322242 malekmoj@tums.ac.ir

Abstract

Background: Hemodialysis is the most common method of renal replacement therapy for treatment of acute and chronic kidney failure. Helicobacter pylori (H. pylori) plays a major role in development of peptic ulcer, gastric neoplasms, and lymphoma as well as increased risk of cardiovascular disorders in hemodialysis patients.

Objectives: In this study the diagnostic values of noninvasive tests [i.e. urea breath test (UBT), helicobacter pylori stool antigen test (HPSA) and serology] in diagnosis of H. pylori infection in hemodialysis patients have been studied.

Patients and Methods: All patients undergoing hemodialysis in Fatemieh Hospital, Semnan, Iran, were enrolled in the study, and their H. pylori status were assessed by using non-invasive tests including UBT, HPSA and serology. Patients with at least two out of 3 positive tests were considered infected with H. pylori.

Results: The sensitivity, specificity, and positive and negative predictive values of the tests used in diagnosing H. pylori infection were 62.5%, 65.4%, 62.5% and 65.4% for UBT, 100%, 72.2%, 58.3% and 100% for serology, and 100%, 75%, 60.9% and 100% for fecal antigen test, respectively.

Conclusions: This study showed that H. pylori serology and stool antigen tests have higher diagnostic values than UBT, and they are more reliable than UBT in diagnosis of H. pylori infection in hemodialysis patients.

Keywords: Helicobacter pylori, Hemodialysis, Urea breath test

Implication for health policy/practice/research/medical education:

Helicobacter pylori in hemodialysis patients play a major role in occurrence of peptic ulcer, gastric neoplasms, lymphoma as well as increased risk of cardiovascular disorders.  

Please cite this paper as:Tamadon MR, Saberi Far M, Soleimani A, Ghorbani R, Semnani V, Malek F, Malek M. Evaluation of noninvasive tests for diagnosis of Helicobacter pylori infection in hemodialysis patients. J Nephropathology. 2013; 2(4): 249-253, DOI: 10.12860/JNP.2013.39

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Revision: 28 Sep 2012
ePublished: 01 Sep 2013
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