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J Nephropathol. 2015;4(2): 32-37.
doi: 10.12860/jnp.2015.07
PMID: 25964886
PMCID: PMC4417667
Scopus ID: 84927145468
  Abstract View: 2705
  PDF Download: 1166

Review

The role of Th1 and Th17 cells in glomerulonephritis

Fatemeh Azadegan-Dehkordi 1, Nader Bagheri 2, Hedayatollah Shirzad 1 * , Mahmoud Rafieian-Kopaei 3

1 Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Prof. Hedayatollah Shirzad, Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. shirzadeh@yahoo.com

Abstract

Context: T helper (Th) cells as an important part of the immune is responsible for elimination of invading pathogens. But, if Th cell responses are not regulated effectively, the autoimmune diseases might develop. The Th17 subset usually produces interleukin-17A which in experimental models of organ-specific autoimmune inflammation is very important.

Evidence Acquisitions: Directory of open access journals (DOAJ), Google Scholar, Embase, Scopus, PubMed and Web of Science have been searched.

Results: Fifty-six articles were found and searched. In the present review article, we tried to summarize the recently published data about characteristics and role of Th1 and Th17 cells and discuss in detail, the potential role of these T helpers immune responses in renal inflammation and renal injury, focusing on glomerulonephritis. Published papers in animal and human studies indicated that autoimmune diseases such as rheumatoid arthritis and multiple sclerosis, classically believed to be Th1-mediated, are mainly derived from a Th17 immune response. Identification of the Th17 subgroup has explained seemingly paradoxical observations and improved our understanding of immune-mediated inflammatory responses.

Conclusions: Secretion of IL-17A, as well as IL-17F, IL-21, IL-22, suggests that Th17 subset may play a crucial role as a pleiotropic pro-inflammatory Th subset. There is experimental evidence to support the notion that Th1 and Th17 cells contribute to kidney injury in renal inflammatory diseases like glomerulonephritis.

Keywords: Renal injury, Glomerulonephritis, Chronic kidney disease, Autoimmune disease

Implication for health policy/practice/research/medical education:

Identification of the Th17 subgroup has explained paradoxical observations and improved our understanding of immune-mediated inflammatory responses. Secretion of IL-17A, as well as IL-17F, IL-21, IL-22, suggests that Th17 subset may play a crucial role as a pleiotropic pro-inflammatory Th subset. There is experimental evidence to support the notion that Th1 and Th17 cells contribute to kidney injury in renal inflammatory diseases like glomerulonephritis.

Please cite this paper as:Azadegan-Dehkordi F, Bagheri N, Shirzad H, Rafieian-Kopaei M. The role of Th1 and Th17 cells in glomerulonephritis. J Nephropathol. 2015; 4(2):32-37. DOI: 10.12860/jnp.2015.07

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Revision: 04 Nov 2014
ePublished: 19 Mar 2015
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