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J Nephropathol. 2017;6(2): 74-80.
doi: 10.15171/jnp.2017.13
PMID: 28491857
PMCID: PMC5418074
Scopus ID: 85008502127
  Abstract View: 2085
  PDF Download: 1277

Original Article

Administration of zinc against arsenic-induced nephrotoxicity during gestation and lactation in rat model

Davood Nasiry Zarrin Ghabaee 1, Fereshteh Talebpour Amiri 2 * , Amir Esmaeelnejad Moghaddam 2, Ali Reza Khalatbary 2, Mehryar Zargari 3

1 Department of Anatomy, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
2 Department of Anatomy, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Clinical Biochemistry,‚Äč Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Ira
*Corresponding author: Fereshteh Talebpour Amiri, Ph.D, Department of Anatomy, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran. ftaleb2001@yahoo.co.uk

Abstract

Background: Free radicals production by toxicity of arsenic (Ar) is most important in the nephrotoxicity. There is accumulating evidence that zinc (Zn), has anti-oxidant properties.

Objectives: The aim of present study was to evaluate protective and ameliorative effects of Zn against Ar-induced nephrotoxicity in rat pups during gestation and lactation.

Materials and Methods: Twenty-four adult pregnant wistar rats were randomly divided into four groups (n = 6). Group one was given vehicle only. Group two received Zn (ZnSO4) at 20 mg/kg/d. Group three received Ar at 5 mg/kg/d as sodium meta-arsenite. Group four received Ar + Zn at the same dose that mentioned in groups of two and three. At the end of the study, 24 hours after the last treatment, samples were killed with overdose of sodium pentobarbital and kidneys were harvested for measuring malondialdehyde (MDA), glutathione (GSH) and histopathological assessment.

Results: The MDA level in kidney was increased in the Ar group, which was decreased after Zn administration in the Ar + Zn group. The GSH level in kidney was decreased in the Ar group, which were increased after Zn administration in the Ar + Zn group. Also, the histopathological changes which were detected in the Ar group attenuated after Zn consumption.

Conclusions: Our findings suggested that administration of Zn during gestation and lactation could have protective and prevent effect in Ar-induced oxidative stress in kidney tissue.

Keywords: Arsenic, Zinc, Nephrotoxicity, Gestation, Lactation

Implication for health policy/practice/research/medical education:

In this experimental study, we found that Zn as an antioxidant agent and ability to cross of placenta, can protect kidney against Ar induced nephrotoxicity during gestation and lactation. The main mechanism of Zn in renoprotective effects was inhibition of oxidative stress by amelioration of lipid peroxidation produced as well as elevation of GSH.

Please cite this paper as: Nasiry Zarrin Ghabaee D, Talebpour Amiri F, Esmaeelnejad Moghaddam A, Khalatbary AR, Zargari M. Administration of zinc against arsenic-induced nephrotoxicity during gestation and lactation in rat model. J Nephropathol. 2017;6(2):74-80. DOI: 10.15171/jnp.2017.13.

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ePublished: 25 Dec 2016
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