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J Nephropathol. 2020;9(1): e04.
doi: 10.15171/jnp.2020.04

Scopus ID: 85078239703
  Abstract View: 634
  PDF Download: 292

Review

Administration of metformin in type 2 diabetes mellitus patients with chronic kidney disease; facts and myths

Mohsen Akhavan Sepahi 1 * ORCID logo, Bhaskar VKS Lakkakula 2 ORCID logo, Steven James Kellner 3 ORCID logo, Rohollah Valizadeh 4 ORCID logo

1 Department of Pediatric Nephrology, School of Medicine and Pediatric Clinical Research of Development Center, Qom University of Medical Sciences, Qom, Iran
2 Department of Zoology, Guru Ghasidas University, Bilaspur, 495009 (CG), India
3 Head International Research and Development, Mesencell Biotech International Ltd, 20-22 Wenlock Road, London, N1 7GU, United Kingdom
4 Department of Epidemiology, Student Research Committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
*Corresponding author: Mohsen Akhavan Sepahi, Email: akhavansepahim@yahoo.com

Abstract

There are few publications reporting adverse effects of metformin for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). Although some of these reports have made big claims about the adverse effects of metformin in patients with renal failure, the majority of studies showed a superior safety profile for metformin compared with other antidiabetic medications in these patients. Further, metformin use is not contributing to an increased incidence of acute kidney injury (AKI). In conclusion, we suggest that a low dose of metformin is safe to use in patients with or without CKD. Multicenter randomized trials are required to further discover the benefits of the risk of metformin therapy in different stages of CKD and its effect on progression of CKD. 
Keywords: Metformin, Type 2 diabetes, Acute kidney injury, Chronic kidney disease, Renal failure, Lactic acidosis, End-stage renal disease, Glomerular filtration rate
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Submitted: 05 Oct 2019
Accepted: 29 Nov 2019
ePublished: 07 Dec 2019
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