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J Nephropathol. 2020;9(1): e03.
doi: 10.15171/jnp.2020.03

Scopus ID: 85078296609
  Abstract View: 532
  PDF Download: 239

Epidemiology and Prevention

Multifaceted role of apolipoprotein L1 risk variants and nephropathy

Mohsen Akhavan Sepahi 1 ORCID logo, Bahram Niknafs 2 * ORCID logo

1 Department of Pediatric Nephrology, School of Medicine, Qom University of Medical Sciences, Qom, Iran
2 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding author: Bahram Niknafs, Email: bahraminik@gmail.com
Keywords: Apolipoprotein L-1, Chronic kidney disease, HIV-associated nephropathy, Membranous nephropathy, Sickle-cell nephropathy, Hypertensive nephropathy, Arterionephrosclerosis, Lupus nephritis, End-stage renal disease

Implication for health policy/practice/research/medical education:

APOL1 protein is encoded by the APOL1 gene in humans and plays a role in innate immunity. The spectrum of APOL1-related nephropathies consists of HIV-associated nephropathy (HIVAN), segmental glomerulosclerosis (FSGS), membranous nephropathy (MGN), sickle-cell nephropathy, hypertensive nephropathy, arterionephrosclerosis, lupus nephritis, microalbuminuria, chronic kidney disease and end-stage renal disease. Moreover, APOL1 nephropathy risk variants are associated with shorter survival of deceased kidney allografts, lower renal function, interstitial and fibrosis glomerulosclerosis.

Please cite this paper as: Akhavan Sepahi, Niknafs B. Multifaceted role of apolipoprotein L1 risk variants and nephropathy. J Nephropathol. 2020;9(1):e03. DOI: 10.15171/jnp.2020.03.

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Abstract View: 532

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Submitted: 04 Nov 2019
Accepted: 30 Nov 2019
ePublished: 05 Dec 2019
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