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J Nephropathol. 2020;9(2): e13.
doi: 10.34172/jnp.2020.13
  Abstract View: 121
  PDF Download: 24

Review

Effect of sirolimus as an immunosuppressive agent on kidney transplantation in patients with diabetes mellitus; a systematic review

Saeedeh Davar 1, Mohsen Mohammad Rahimi 2 ORCID logo, Maasoumeh Mahdi Akhgar 3 * ORCID logo, Sajjad Saei 4

1 Department of Biostatistics and Epidemiology, Urmia University of Medical Sciences, Urmia, Iran
2 Nephrology and kidney Transplant Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Biostatistics and Epidemiology, School of Health Hamadan University of Medical Sciences & Health Services, Hamadan, Iran
4 Urmia University of Medical Sciences, Urmia, Iran
*Corresponding author: Maasoumeh Mahdi Akhgar, Email: maasoumehakhghar@gmail.com

Abstract

Introduction: Sirolimus is a macrolide and a type of immunosuppressant drug to prevent rejection of transplanted organs. This drug inhibits the activation of T and B lymphocytes and reduces the production of interleukin-2 (IL-2). Objectives: This study aimed to review the effect of sirolimus in kidney transplantation in patients with diabetes mellitus as a systematic review.

Materials and Methods: International databases including PubMed, Web of Science and Scopus were considered for search of English articles by 29 June 2019. Twenty-one published articles were finally entered into the study. Keywords were sirolimus, rapamune, rapamycin, diabetes mellitus and kidney transplantation or a combination of them in the title/abstracts. Treatment using a combination of sirolimus and tacrolimus were excluded.

Results: There were more than 3244 subjects reviewed in this systematic review including 21 published articles (Total population of 21 articles: 3244 people).

Conclusion: According to the results, sirolimus-based immunosuppression for preventing kidney transplantation is effective and has a low-risk in diabetic patients resulting in suitable glucose control.

Keywords: Sirolimus, Diabetes mellitus, Kidney transplantation, End-stage renal disease

Implication for health policy/practice/research/medical education:

Sirolimus-based immunosuppression for preventing kidney transplantation is effective and has a low-risk in diabetic patients.

Please cite this paper as: Davar S, Mohammad Rahimi M, Mahdi Akhgar M, Saei S. Effect of sirolimus as an immunosuppressive agent on kidney transplantation in patients with diabetes mellitus; a systematic review. J Nephropathol. 2020;9(2):e13. DOI: 10.34172/jnp.2020.13.

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Submitted: 10 Aug 2019
Accepted: 27 Nov 2019
ePublished: 26 Dec 2019
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