J Nephropathol. 2019;8(3): e26.
doi: 10.15171/jnp.2019.26
  Abstract View: 44
  PDF Download: 19

Original Article

Urinary podocin level as a predictor of diabetic kidney disease 

Abdelbassit Shaarawy 1 ORCiD, Maha Abdelmoneim Behairy 1 * , Somia Abdelhameed Bawady 2, Hoda Ahmed Abdelsattar 2 * , Eman Shadad 3

1 Internal Medicine and Nephrology Department, Ain Shams University, Faculty of Medicine, Cairo, Egypt
2 Clinical Pathology Department, Ain Shams University, Faculty of Medicine, Cairo, Egypt
3 Damanhour Medical National Institute, Nephrology Department, El Beheira, Egypt
*Corresponding author: Hoda Ahmed Abdelsattar, E-mail: Email: hoda_sattar@hotmail.com

Abstract

Background: Albuminuria showed to be a deteriorating condition in diabetic kidney disease (DKD) associated with high morbidity and mortality. A need for a novel marker for early detection of DKD development and progression becomes mandating.

Objective: To study the clinical value of urinary podocin as an early marker of diabetic kidney disease and its association with severity of the disease.

Patients and Methods: This study included 45 individuals with type 2 DM whose GFR >60 mL/min/1.73 m2 , recruited from Ain Shams University Hospital, Cairo, Egypt. Patients were further divided into three groups according to urinary albumin/creatinine ratio (ACR). In addition to, ten healthy volunteers serving as the control group was enrolled in the study. Routine chemistry including serum creatinine, fasting blood glucose (FBG), HbA1c, albumin, lipid profile, urine analysis, ACR and urinary podocin quantification were conducted for all participants (by ELISA method).

Results: Podocin was higher in patients with ACR <30 mg/g, ACR 30-299 mg/g and ACR ≥ 300 mg/g versus healthy controls, respectively (P<0.001). Both GFR and serum albumin showed highly significant negative correlations with urinary podocin. Significant positive correlations were detected between urinary podocin with blood urea nitrogen (BUN), serum creatinine, FBG, HbA1c, cholesterol, and triglyceride levels.

Conclusions: Urinary podocin is assumed to be a promising marker for early DKD detection in type 2 DM patients.

Implication for health policy/practice/research/medical education:

The development of diabetic kidney disease (DKD) needs early detection and management aiming to decrease the incidence of endstage kidney failure. We believe that our study has implication for the diabetic patients. This study included 45 patients with types 2 diabetes mellitus (DM). We found urinary podocin is a promising marker for early DKD detection in types 2 DM.

Please cite this paper as: ElShaarawy A, Abdelmoneim Behairy M, Abdelhameed Bawady S, Ahmed Abdelsattar H, Shadad E. Urinary podocin level as a predictor of diabetic kidney disease. J Nephropathol. 2019;8(3):e26. DOI: 10.15171/jnp.2019.26.

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Submitted: 09 Apr 2018
Accepted: 19 Jul 2018
First published online: 16 Aug 2018
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