J Nephropathol. 2020;9(4): e37.
doi: 10.34172/jnp.2020.37

Scopus ID: 85085283096
  Abstract View: 511
  PDF Download: 285


Infectious pathways of SARS-CoV-2 in renal tissue

Wenqing Yin 1 * ORCID logo, Ping L. Zhang 2

1 Department of Nephrology, Boston Medical Center, Boston, MA, USA
2 Division of Anatomic Pathology, Beaumont Labs, Beaumont Health, Royal Oak, MI, USA
*Corresponding author: Wenqing Yin, M.D., Ph.D., Renal Section, Department of Medicine, Boston University Medical Center. Evans Biomedical Research Center, X-530, Boston, MA 02118, USA, Email: wenqing.yin@bmc.org
Keywords: COVID19, Acute kidney injury, Collapsing focal segmental glomerulosclerosis, Angiotensin converting enzyme 2

Implication for health policy/practice/research/medical education:

Coronavirus disease in 2019 (COVID-19) has spread around the world and caused significantly pandemic mobility and mortality. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) usually infects lungs first and involves other organs including kidneys subsequently. Acute kidney injury and proteinuria in patients with COVID19 are resulted from the direct infection of the spikycrowned viruses to proximal tubules and podocytes, leading to acute tubular injury and collapsing focal segmental glomerulosclerosis. Therefore treatment strategy should target against the direct infection of SARS-CoV2 to the renal tissue.

Please cite this paper as: Yin W, Zhang PL. Infectious pathways of SARS-CoV-2 in renal tissue. J Nephropathol. 2020;9(4):e37. DOI: 10.34172/jnp.2020.37.

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Submitted: 10 May 2020
Accepted: 13 May 2020
ePublished: 14 May 2020
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