Logo-jnp
J Nephropathol. 2020;9(4): e38.
doi: 10.34172/jnp.2020.38
  Abstract View: 88
  PDF Download: 42

Min Review

Are statins toxic or safe for kidney diseases? An updated mini-review study

Shadi Botshekan 1 ORCID logo, Banafsheh Yalameha 2 * ORCID logo

1 Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Nickan Research Institute, Isfahan, Iran
*Corresponding author: Banafsheh Yalameha, Email: Yalameha.b7@gmail.com

Abstract

Statins, as the most important cholesterol-lowering agents, inhibit the production of blood cholesterol by blocking an enzyme called the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-COA) reductase. Statins have beneficial effects in some tissues during various injuries. Recent evidence suggests that unlike the beneficial effects of statins, administration of high doses of these drugs may increase renal impairment, although more research is needed in this regard. Therefore, this study aimed to evaluate the possible effect of different doses of statins on the morphology and function of the kidney tubular cells.
Keywords: Statin, HMG-COA reductase, Renal toxicity

Implication for health policy/practice/research/medical education:

The present study aimed to evaluate the possible effect of different doses of statins on the morphology and function of the kidney tubular cells. The results indicated that statins have beneficial effects on renal disorders. However, more attention should be paid to high-dose of statins in clinical conditions.

Please cite this paper as: Botshekan S, Yalameha B. Are statins toxic or safe for kidney diseases? An updated mini-review study. J Nephropathol. 2020;9(4):e38. DOI: 10.34172/jnp.2020.38.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 88

Your browser does not support the canvas element.


PDF Download: 42

Your browser does not support the canvas element.

Submitted: 07 Mar 2020
Accepted: 02 May 2020
ePublished: 14 May 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)