J Nephropathol. 2019;8(4):37-37.
doi: 10.15171/jnp.2019.37
  Abstract View: 60
  PDF Download: 44

Original Article

Perineural invasion, Gleason score and prostate specific antigen; is there any association?

Mohammad Yazdani 1 ORCiD, Ali Karami 1 * ORCiD, Emadeddin Yazdani-Kachouei 2 ORCiD, Farhad Tadayon 1 ORCiD

1 Isfahan Urology and Kidney Transplantation Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Mazandaran University of Medical Sciences, Ramsar, Sari, Iran
*Corresponding author: Ali Karami, Email: Email: Ali72karamii@gmail.com

Abstract

Introduction: Prostatic cancer is one of the most common malignancies among males. Perineural invasion (PNI) is a common finding of prostate cancer associated with more aggressive malignancies.

Objectives: The current study was conducted to assess the association of PNI with serum prostate specific antigen (PSA) and Gleason score.

Patients and Methods: This analytical cross-sectional study conducted on 354 known cases of prostatic cancer (2015 until 2017). Patients’ last PSA and Gleason score wit h presence/lack of PNI in their prostate biopsies were recorded. The association of PNI with PSA and Gleason score was assessed.

Results: Serum level of PSA and Gleason core were significantly higher in patients with PNI (P< 0.001 for both). Gleason score was independently a predictor of PNI (odds ratio [OR]: 3.05, 95% CI:2.32- 4.001; P=0.001). Serum PSA level of 17 ng/mL had specificity of 90.3% and sensitivity of 42.7% for prediction of PNI.

Conclusion: In this study we found, Gleason score is independently a prognostic factor of PNI among cases undergone prostate biopsy. In addition, serum PSA level of 17 ng/mL was 90.3% specific and 42.7% sensitive for PNI occurrence. However, our findings require further evaluations by larger studies.

Implication for health policy/practice/research/medical education:

In an analytical cross-sectional study conducted on 354 known cases of prostatic cancer, we found, Gleason score is independently a prognostic factor of perineural invasion among cases undergone prostate biopsy.

Please cite this paper as: Yazdani M, Karami A, Yazdani-Kachouei E, Tadayon F. Perineural invasion, Gleason score and prostate specific antigen; is there any association? J Nephropathol. 2019;8(4):e37. DOI: 10.15171/jnp.2019.37.

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Submitted: 19 Apr 2018
Accepted: 16 Aug 2019
First published online: 10 Sep 2019
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