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J Nephropathol. 2017;6(4): 282-289.
doi: 10.15171/jnp.2017.47

Scopus ID: 85036497079
  Abstract View: 1725
  PDF Download: 1037

Original Article

Hypoparathyroidism versus hyperparathyroidism in pediatric dialysis patients; a single center study

Mitra Naseri *

1 Department of Pediatric Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding author: Mitra Naseri, Naserim@mums.ac.ir

Abstract

Background: Abnormalities in calcium, phosphorous and parathyroid hormone (PTH) metabolisms are common in dialysis patients. Reaching target levels for these serologic factors and calcium × phosphorous products is recommended to minimize cardiovascular events.

Objectives: The aim of this study was to examine calcium, phosphorous and intact PTH (iPTH) abnormalities in a group of dialysis patients.

Patients and Methods: Bone minerals status and iPTH levels were assessed in 46 dialysis patients aged 19-300 (165.2 ± 75.73) months. Low and high Ca dialysate solutions routinely were used for hemodialysis (63%) and peritoneal dialysis (30.4%) patients respectively. Comparisons between groups were performed with considering age (≤5, 6-10, and > 10
years), gender and modality of dialysis.

Results: Serum calcium and corrected calcium levels were significantly higher in peritoneal dialysis (PD) patients. Hypoparathyroidism was the most frequent iPTH abnormality (58.7%). It was more prevalent in males. Hyperparathyroidism was more frequent in females.

Conclusions: We found that hypoparathyroidism is the most prevalent PTH abnormality. We also noted that patients on peritoneal dialysis are more prone to develop this form of PTH abnormality. We found that phosphate control is better in peritoneal dialysis vs. hemodialysis cases.

Keywords: CKD, Hemodialysis, Peritoneal dialysis, PTH, Parathormone

Implication for health policy/practice/research/medical education:

In an observational cross-section study in dialysis patients, we found that over suppression of iPTH and hypoparathyroidism was the most common abnormality.

Please cite this paper as: Naseri M. Hypoparathyroidism versus hyperparathyroidism in pediatric dialysis patients; a single center study. J Nephropathol. 2017;6(4):282-287. DOI: 10.15171/jnp.2017.47.

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Submitted: 04 Dec 2016
Accepted: 28 Jan 2017
ePublished: 08 Feb 2017
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