J Nephropathol. 2019;8(1): e3.
doi: 10.15171/jnp.2019.03
  Abstract View: 280
  PDF Download: 235

Original Article

Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney function

Heshmatolah Shahbazian 1, Samaneh Salehipour Bavarsad 2, Hamid Yaghooti 3 * , Seyyed Mostafa Saadati 4, Samaneh Olapour 5

1 Department of Nephrology, Golestan General Hospital, Diabetes and CKD Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Hyperlipidemia Research Center, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Nuclear Medicine Department, Golestan General Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding author: Hamid Yaghooti, Email: Yaghooti-h@ajums.ac.ir

Abstract

Background: Advanced glycation end-products (AGEs) cause proinflammatory responses and macromolecular damages. Advanced oxidation protein products (AOPPs) are protein biomarkers for oxidative stress. Levels of AGEs and AOPPs increase with the progression of chronic renal dysfunction.

Objectives: In this study, we aimed to measure these species in patients with renal transplantation and to analyze their correlation with the measured glomerular filtration rate (GFR) and renal function parameters.

Patients and Methods: Eighty renal transplant patients and normal subjects were recruited. GFR was measured by the two-sample plasma method with technetium-99m-labeled diethylenetriaminepentaacetic acid (TC99m-DTPA) clearance. Biochemical measurements included creatinine, cystatin C, urea, total protein, and pentosidine. Serum AGEs were determined using a fluorometric assay and AOPPs were estimated spectrophotometrically.

Results: The measured GFR found to be significantly decreased in renal transplant patients compared to the control subjects (P< 0.001). Levels of AGEs, AOPPs, serum creatinine, and cystatin C were increased in renal transplant patients with lower values of measured GFR (mGFR). A significant association between the levels of AGEs species (serum fluorescence and pentosidine) and mGFR when adjusted for creatinine and other risk factors in multiple linear regression model analysis was found (P=0.05 and P=0.001, respectively).

Conclusions: This study demonstrated increased levels of pentosidine and AGEs in transplant recipients were associated with decreased mGFR. Their accumulation can be predictive for the progression of chronic allograft loss of function.

Implication for health policy/practice/research/medical education:

Advanced glycation end-products (AGEs) are harmful species which are involved in many pathological conditions such as complications of diabetes and chronic allograft nephropathy. Studying the involvement and damages of these compounds in renal transplant patients can shed more light to the molecular mechanisms of this situation and may be implicated in the early detection and treatment of chronic deteriorations of the transplanted kidney.

Please cite this paper as: Shahbazian H, Salehipour Bavarsad S, Yaghooti H, Saadati SM, Olapour S. Increased level of advanced glycation end-products in renal transplant patients is associated with decreased measured GFR and grafted kidney function. J Nephropathol. 2019;8(1):e03. doi: 10.15171/jnp.2019.03

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Submitted: 07 May 2017
Accepted: 23 Oct 2017
First published online: 19 Dec 2017
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