J Nephropathol. 2018;7(2): 79-82.
doi: 10.15171/jnp.2018.19

Scopus ID: 85046002935
  Abstract View: 1513
  PDF Download: 774

Original Article

Angiotensin 1-7 administration alters baroreflex sensitivity and renal function in sympathectomized rats

Mohammad Karim Azadbakht, Mehdi Nematbakhsh *

1 Water and Electrolytes Research Center/Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding author: Prof. Mehdi Nematbakhsh, Ph.D, nematbakhsh@med.mui.ac.ir


Background: Renin-angiotensin system (RAS) plays an important role in cardiovascular and kidney functions to regulate the systematic blood pressure. The baroreflex sensitivity (BRS) index is a quantitative index that was considered as a prognostic indicator for cardiovascular system risk which is known as heart rate change to blood pressure change ratio ( HR MAP ∆ ∆ ). Sympathetic nerve is an arm of the BRS which may be influenced by RAS vasodilatory arm function.

Objectives: To determine the role of angiotensin 1-7 (Ang1-7) accompanied by bilateral renal denervation (RDN) on BRS and renal function.

Methods: Male and female anesthetized Wistar rats were subjected to RDN and treated with Ang1-7 (300 and 1000 ng.kg-1.min-1). Mean arterial pressure (MAP) and heart rate (HR) responses to phenylephrine (PE) infusion were measured to determine BRS index. As kidney function markers, the creatinine clearance (CrCl) and urine flow (UF) were also determined.

Results: The results showed that BRS increased significantly in RDN male rats treated with Ang1-7 compared to vehicle (P<0.05). BRS attenuates significantly in RDN male rats treated with vehicle or Ang1-7 when compared with non-RDN (control). In female rats, the BRS decreased significantly in Ang1-7 treated group (P<0.05). Also, the BRS was significantly different between non-RDN and RDN female rats treated with Ang1-7 (P<0.05). The ClCr in female and UF in both genders increased by Ang1-7 infusion in RDN and non-RDN rats. The alteration of serum nitrite level by Ang1-7 in non-RDN and RDN groups was gender related.

Conclusion: The Ang1-7 infusion could alter the BRS index in RDN rat’s gender dependently. The ClCr response to Ang1-7 infusion in male rats was dose related.

Keywords: Angiotensin 1-7, Phenylephrine, Baroreflex sensitivity, Renal denervation, Renal function, Nitric oxide

Implication for health policy/practice/research/medical education:

To find the role of renal sympathectomy and Ang1-7 infusion in renal function and BRS index.

Please cite this paper as: Azadbakht MK, Nematbakhsh M. Angiotensin 1-7 administration alters baroreflex sensitivity and renal function in sympathectomized rats. J Nephropathol. 2018;7(2):79-82. DOI: 10.15171/jnp.2018.19.

First Name
Last Name
Email Address
Security code

Abstract View: 1513

Your browser does not support the canvas element.

PDF Download: 774

Your browser does not support the canvas element.

Submitted: 02 Mar 2017
Accepted: 04 Sep 2017
ePublished: 27 Sep 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)