J Nephropathol. 2018;7(2): 83-87.
doi: 10.15171/jnp.2018.20

Scopus ID: 85045977122
  Abstract View: 1752
  PDF Download: 1019

Original Article

Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicity

Shirin Asgharian, Hasan Hoseinkhani, Elham Bijad, Zahra Lorigooini, Mahmoud Rafieian-Kopaei *

1 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding author: Prof. Mahmoud Rafieian-Kopaei, Ph.D; Email: rafieian@yahoo.com


Background: In the recent years, the prevalence of metal-induced toxicity, especially leadinduced toxicity, has increased considerably. Metals including lead cause oxidative stress. Therefore Rheum ribes L. as a medicinal plant with antioxidant activity may reduce the complications of these toxicities.

Objectives: The aim of the current study was to investigate the protective effect of hydroalcoholic R. ribes L. extract in male rat model of lead acetate-induced nephrotoxicity.

Materials and Methods: In this experimental study, 40 male Wistar rats were randomly assigned to four groups: Normal saline (control) group, positive control group treated with 0.6 g/L/d of lead acetate in drinking water, and two R. ribes groups treated with 200 and 400 mg/kg/d of R. ribes extract in addition to lead acetate for 10 days. After treatment, the rats were anesthetized, blood samples were taken, and kidneys were removed and fixed in 10% formalin. Then, serum antioxidant capacity was measured and kidney tissue specimens histopathologically studied.

Results: Serum antioxidant capacity was significantly different between lead acetate group and the group treated with lead acetate + R. ribes extract (400 mg/kg). Additionally mice receiving lead acetate + R. ribes extract (400 mg/kg) had significantly higher antioxidant capacity than the control group (P<0.05). Treatment of lead acetate-treated rats with R. ribes extract significantly prevented damage to their kidney tissues.

Conclusions: Rheum ribes extract can prevent lead-induced kidney damage, and therefore exposure to lead acetate by people are recommended to consume this extract.

Keywords: Rheum ribes L., Lead acetate, Nephrotoxicity, Antioxidant capacity, Metal-induced toxicity

Implication for health policy/practice/research/medical education:

Rheum ribes L. extract could significantly prevent lead acetate-induced nephrotoxicity in rat.

Please cite this paper as:Asgharian S, Hoseinkhani H, Bijad E, Lorigooini Z, Rafieian-Kopaei M. Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicity. J Nephropathol. 2018;7(2):83-87. DOI: 10.15171/jnp.2018.20.

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Submitted: 15 Aug 2017
Accepted: 21 Sep 2017
ePublished: 13 Dec 2017
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