J Nephropathol. 2018;7(3): 207-209.
doi: 10.15171/jnp.2018.42

Scopus ID: 85049644362
  Abstract View: 1687
  PDF Download: 921

Case Report

Syndrome of inappropriate antidiuretic hormone as the initial presentation in Guillain-Barré syndrome

Divya Asti, Nicholas Fuca, Jiyoung Wong, Bindu Madhavi Mudduluru, Elie El-Charabaty *

1 Department of Internal Medicine, Department of Nephrology, Staten Island University hospital, Northwell Health, NY, United States
*Corresponding author: Elie El-Charabaty, Email: eelcharabaty@northwell.edu


Background: Guillain-Barré syndrome (GBS) is an autoimmune disease damaging the peripheral nervous system. It commonly presents as rapidly progressing bilateral symmetrical motor weakness. There has been known association of syndrome of inappropriate antidiuretic hormone (SIADH) in patients with GBS though it is rare.

Case Presentation: We report a patient with rare clinical presentation of SIADH before the onset of motor deficits in GBS.

Conclusions: SIADH as an initial finding in patients with GBS is very rare. This case report emphasizes the importance of early detection of SIADH in GBS to avoid delay in treatment. 

Keywords: Guillain-Barré syndrome (GBS), Hyponatremia, Syndrome of inappropriate antidiuretic hormone (SI

Implication for health policy/practice/research/medical education:

Our case report emphasizes that SIADH could precede the development of profound motor deficit in patients with GuillainBarré syndrome. Physicians should be aware of this rare presentation to prevent delays in diagnosis and proper treatment.

Please cite this paper as:Asti D, Fuca N, Wong J, Mudduluru BM, El-Charabaty E. Syndrome of inappropriate antidiuretic hormone as the initial presentation in Guillain-Barré syndrome. J Nephropathol. 2018;7(3):207-209. DOI: 10.15171/jnp.2018.42.

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Submitted: 27 Sep 2018
Accepted: 05 Jan 2018
ePublished: 08 Feb 2018
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