J Nephropathol. 2019;8(1): e01.
doi: 10.15171/jnp.2019.01

Scopus ID: 85066031527
  Abstract View: 1330
  PDF Download: 677


Renoprotective impact of angiotensin 1-7: Is it certain? 

Mehdi Nematbakhsh 1,2,3 *

1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
3 IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran
*Corresponding author: Prof. Mehdi Nematbakhsh, Ph.D, Email: nematbakhsh@med.mui.ac.ir


The two important arms of renin angiotensin system (RAS) are angiotensin II (Ang II) and angiotensin1-7 (Ang1-7). Both of these peptides are present in the kidney, while the renal hemodynamic responses to these peptides act differently in kidney circulation. For this short-review, we used a variety of sources including PubMed, Google Scholar, and Scopus. Although in normal physiological condition, Ang1-7 has been known as an inactive agent in the renal system, however in past years many experimental and clinical reports indicated the protective role of Ang1-7 in renal hemodynamics and functions under different circumstances. In the current article, the possible renoprotective role of Ang1-7 was briefly reviewed. 
Keywords: Renin angiotensin system, Angiotensin II, Angiotensin1-7, Vascular endothelium, Kidney injury, Bradykinin receptors

Implication for health policy/practice/research/medical education:

The protective role of angiotensin 1-7 in renal system mostly related to the improvement of endothelial function or struggle with serious hazard and damage induced by angiotensin II in the kidney.

Please cite this paper as: Nematbakhsh M. Renoprotective impact of angiotensin 1-7: Is it certain? J Nephropathol. 2019;8(1):e01. DOI: 10.15171/jnp.2019.01.

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Abstract View: 1330

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Submitted: 07 Feb 2018
Accepted: 29 Jun 2018
ePublished: 06 Aug 2018
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