J Nephropathol. 2019;8(4):35-35.
doi: 10.15171/jnp.2019.35
  Abstract View: 77
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Original Article

Does fibroblast growth factor 23 correlates with volume status in hemodialysis patients?

Farzanehsadat Minoo 1,2 ORCiD, Azam Alamdari 1,2 * ORCiD, Hamed Karimi 1

1 Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding author: Azam Alamdari, Email: Email: a-alamdari@sina.tums.ac.ir

Abstract

Introduction: Volume overload is a known risk factor for cardiovascular disease and stroke in hemodialysis patients. The use of fibroblast growth factor 23 (FGF23) as a volume overload marker has been validated in multiple studies.

Objectives: This is a prospective cross-sectional study considering the association between FGF23 and bioimpedance-measured volume overload in hemodialysis patients.

Patients and Methods: Bioimpedance analysis was performed on 43 hemodialysis patients at the end of hemodialysis to evaluate the remaining volume overload and serum FGF23 was measured before hemodialysis.

Results: The results indicated no significant correlation between mean serum FGF23 levels and volume overload in hemodialysis patients (P=0.824).

Conclusion: Although this study did not show any association between volume overload and FGF23, further studies are needed to define the role of FGF23 as a volume overload marker.

Implication for health policy/practice/research/medical education:

In this study, we aimed to assess the correlation between FGF-23 and overload in hemodialysis patients. We found fibroblast growth factor 23 (FGF23) has not any significant association with overload in hemodialysis patients.

Please cite this paper as: Minoo F, Alamdari A, Karimi H. Does fibroblast growth factor 23 correlates with volume status in hemodialysis patients?. J Nephropathol. 2019;8(4):e35. DOI: 10.15171/jnp.2019.35.

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Submitted: 04 Nov 2019
Accepted: 09 Jan 2019
First published online: 29 Jan 2019
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