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J Nephropathol. 2020;9(3): e24.
doi: 10.34172/jnp.2020.24

Scopus ID: 85083228796
  Abstract View: 416
  PDF Download: 135

Original Article

The association of serum dephosphorylated-uncarboxylated matrix gamma carboxyglutamate protein (dp-ucMGP) as a marker of vascular vitamin K status with allograft function in kidney transplant recipients

Vahideh Ebrahimzadeh Attari 1 ORCID logo, Zahra Shahvegharasl 2 ORCID logo, Pouya Fathalizadeh 3, Sajjad Pourasghary 4 ORCID logo, Mohammadali Mohajel Shoja 5, Bahram Niknafs 3 ORCID logo, Mohammad Reza Ardalan 3 * ORCID logo

1 Maragheh University of Medical Sciences, Maragheh, Iran
2 Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
5 Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA

Abstract

Introduction: Kidney transplantation has considerably increased the survival and life quality of patients with end-stage renal disease.

Objectives: The current study was designed to investigate the circulating level of dephosphorylateduncarboxylated matrix gamma carboxyglutamate protein (dp-ucMGP) as a marker of vitamin K status and vascular calcification in kidney transplant recipients as well as its association with the allograft function.

Patients and Methods: In this cross-sectional study, 90 eligible kidney transplant recipients were evaluated in the post-transplant phase (about 6-12 months after kidney transplantation). The serum levels of dp-ucMGP, urea, creatinine and other biochemical indices were determined.

Results: The mean serum level of dp-ucMGP was 3.78±3.79 µg/L. Most of the participants (80%) had a normal range of serum dp-ucMGP (<4 µg/L). However, 10 % had high serum dp-ucMGP (>12 µg/L). Serum dp-ucMGP did not have any statistical significant association with serum urea, creatinine and kidney function (P>0.05).

Conclusion: Further epidemiologic studies are needed to assess the time trends of dp-ucMGP after renal transplant and its relation to kidney function, since high serum level of dp-ucMGP may make kidney transplant recipients prone to various cardiovascular disease (CVD) and transplant rejection.

Keywords: Matrix Gla Protein, Kidney function, Kidney transplant, Vascular calcification, Vitamin K, End-stage renal disease, Chronic kidney disease, Cardiovascular disease

Implication for health policy/practice/research/medical education:

In a study on 90 kidney transplant recipients in the post-transplant phase, we found, the mean serum level of dephosphorylateduncarboxylated matrix gamma carboxyglutamate protein (dp-ucMGP) was in normal range. However, a small percentage of participants had high serum dp-ucMGP (>12 µg/L). Serum dp-ucMGP did not have any statistical significant association with serum urea, creatinine and kidney function, since previous studies showed high serum level of dp-ucMGP may make kidney transplant recipients susceptible to the cardiovascular events and transplant rejection.

Please cite this paper as: Ebrahimzadeh Attari V, Shahvegharasl Z, Fathalizadeh P, Pourasghary S, Mohajel Shoja M, Niknafs B, Ardalan M. The association of serum dephosphorylated-uncarboxylated matrix gamma carboxyglutamate protein (dp-ucMGP) as a marker of vascular vitamin K status with allograft function in kidney transplant recipients. J Nephropathol. 2020;9(3):e24. DOI: 10.34172/jnp.2020.24.

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Abstract View: 416

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Submitted: 02 Sep 2019
Accepted: 07 Nov 2019
ePublished: 25 Nov 2019
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