Logo-jnp
J Nephropathol. 2020;9(2): e19.
doi: 10.34172/jnp.2020.19
  Abstract View: 185
  PDF Download: 31

Case Report

A case of Fanconi syndrome as a complication of treatment with a checkpoint inhibitor in a patient with hepatocellular carcinoma

Mohammad Tinawi 1, Bahar Bastani 2 * ORCID logo

1 Nephrology Specialists, P.C. 801 MacArthur Blvd., Ste. 400A, Munster, IN 46321, USA
2 Division of Nephrology, Saint Louis University Health Sciences Center, 3635 Vista Ave, St. Louis, MO, USA
*Corresponding author: Prof. Bahar Bastani, M.D., Email: Bahar.Bastani@health.slu.edu

Abstract

Introduction: Immune checkpoint inhibitors (CPIs) represent novel new cancer immunotherapy agents. The use of nivolumab has been linked with immune mediated acute interstitial nephritis (AIN).

Case Presentation: We present the case of a patients with recurrent hepatocellular carcinoma who developed severe Fanconi syndrome, as evidenced by hyperchloremic metabolic acidosis, hypokalemia, hypophosphatemia, glucosuria, aminoaciduria, 8 months after initiating treatment with nivolumab, without any evidence of acute renal insufficiency.

Conclusion: Clinicians need to be aware of the renal side effects of new novel cancer immunotherapy agents, such as, immune CPIs

Keywords: Checkpoint inhibitors, Cancer immunotherapy, Fanconi syndrome, Hyperchloremic metabolic acidosis, Acute interstitial nephritis, Hepatocellular carcinoma

Implication for health policy/practice/research/medical education:

Clinicians need to be aware of the renal side effects of new novel cancer immunotherapy agents, such as, immune checkpoint inhibitors.

Please cite this paper as: Tinawi M, Bastani B. A case of Fanconi syndrome as a complication of treatment with a checkpoint inhibitor in a patient with hepatocellular carcinoma. J Nephropathol. 2020;9(2):e19. DOI: 10.34172/jnp.2020.19.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 185

Your browser does not support the canvas element.


PDF Download: 31

Your browser does not support the canvas element.

Submitted: 04 Jul 2019
Accepted: 27 Jul 2019
ePublished: 10 Sep 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)