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J Nephropathol. 2021;10(1): e07.
doi: 10.34172/jnp.2021.07
  Abstract View: 235
  PDF Download: 101

Original Article

The predictive value of serum klotho in diabetes mellitus and hypertension

Kamal Khademvatani 1 ORCID logo, Zahra Yekta 2 ORCID logo, Mirhosein Seyed Mohammadzad 3 ORCID logo, Shahriar Khanahmadi 4 * ORCID logo, Roghaiyeh Afsargharehbagh 5 ORCID logo, Leila Majdi 4 ORCID logo, Alireza Rostamzadeh 6 ORCID logo, Mojgan Hajahmadipoor Rafsanjani 5 ORCID logo, Ali Soleimany 6 ORCID logo, Elham Niknejad 7 ORCID logo, Mohammad Reza Zolfaghari 8 ORCID logo, Shima Khanahmadi 4, Zeinab Pourmansouri 9 ORCID logo, Reza Karimi 4 ORCID logo

1 Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran
2 Department of Community Medicine, Urmia University of Medical Sciences, Urmia, Iran
3 Patient Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran
4 Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
5 Department of Cardiology, Shohada Hospital, Urmia University of Medical sciences, Urmia, Iran
6 Urmia University of Medical Sciences, Urmia, Iran
7 Department of Dentistry, Urmia University of Medical Sciences, Urmia, Iran
8 Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Urmia University of Medical Sciences, Urmia, Iran
9 Department of Clinical Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding author: Shahriar Khanahmadi, Email: shahriar.khanahmadi@gmail.com, khademvatani.k@umsu.ac.ir

Abstract

Introduction: Klotho allele status is associated with increased risk of cardiovascular diseases, diabetes and hypertension.

Objectives: To determine if serum klotho level was lower among diabetic and hypertensive patients compared to control group.

Patients and Methods: This was a cross-sectional study of 90 participants. Thirty pure diabetic patients and 30 participants with pure hypertension were compared with the healthy control group. Multiple logistic regressions were used to examine the association between serum klotho and diabetes and hypertension. We also tested the cut off point of serum klotho to predict hypertension and diabetes by using ROC (receiver operating characteristic) curve.

Results: The level of serum klotho was significantly lower in diabetic and hypertensive patients. Participants with higher klotho were less likely to have diabetes and hypertension [OR: 0.48, 95% CI (0.22-0.81)] even after adjustment for covariates. ROC curve for diabetes and hypertension indicated 0.8 area under the curve which was statistically significant.

Conclusion: This study found that serum klotho was associated with lower odds of diabetes and hypertension. Further longitudinal studies are necessary to confirm this finding.

Keywords: Klotho, Diabetes, Hypertension, Predictive value

Implication for health policy/practice/research/medical education:

Klotho is a recently known anti-aging protein. Diabetes and hypertension as two major public health issues associate with increased risk of cardiovascular complications. The level of serum klotho was significantly lower in diabetic and hypertensive patients. Serum klotho was associated with lower odds of diabetes and hypertension and participants with higher klotho were less likely to have diabetes and hypertension.

Please cite this paper as: Khademvatani K, Yekta Z, Seyed Mohammadzad M, Khanahmadi S, Afsargharehbagh R, Majdi L, et al. The predictive value of serum klotho in diabetes mellitus and hypertension. J Nephropathol. 2021;10(1):e07. DOI: 10.34172/jnp.2021.07.

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Submitted: 15 Apr 2020
Accepted: 21 Jun 2020
ePublished: 20 Jul 2020
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