Logo-jnp
J Nephropathol. 2012;1(3): 170-176.
doi: 10.5812/nephropathol.8115
PMID: 24475411
PMCID: PMC3886148
Scopus ID: 84877096793
  Abstract View: 2906
  PDF Download: 1222

Original Article

Association between helicobacter pylori infection and body mass index, before and after eradication of infection in hemodialysis batients

Mojgan Jalalzadeh 1, Mohammad Hassan Ghadiani 2 * , Nouraddin Mousavinasab 3

1 Departments of Nephrology , Imam Hossein Hospital , Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Department of Nephrology. Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Department of Social Medicine , Zanjan University of Medical Sciences, Zanjan, Iran.
*Corresponding author: Dr. Mohammad Hassan Ghadiani, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Telephone/Fax:+982122432570 j_mojgan@yahoo.com

Abstract

Background: In dialysis patients, chronic infections have been associated with cachexia and anorexia.

Objectives: This study was carried out to determine the association between Helicobacter pylori (HP) infection and body mass index (BMI) in hemodialysis (HD) patients.

Patients and Methods: Ninety eight patients were divided into two groups of negative (group 1) and positive (group 2), for HP. BMI of all patients was measured at the beginning and in group2 after six months following eradication of HP. Before dialysis, various paraclinical parameters were checked at the same intervals.

Results: Fifty-nine patients were enrolled in group 1 and 39 patients in group 2. The means of BMI in groups 1 and 2 were 23.4±3.7 and 25.8±4.4kg/m², respectively. Prior to the study, there was no significant difference for BMI, duration of HD and paraclinic data between two groups. Group 2 took anti HP therapy and eradication occurred in 30 of them. In this group six months after eradication of HP, the BMI was significantly decreased from 25.02±4.4 to 24.4±4.0 kg/m² (P = 0.001). Also six months following the eradication of HP, the mean of serum albumin level was significantly declined from 4.2 to 3.7 g/L (P<0.001). There was also significant decrease in cholesterol (P=0.001), blood urea nitrogen (P=0.005) and calcium (P=0.02). However, significant increase in hemoglobin level was also seen (P=0.03).

Conclusions: The results of this study show that eradication of HP has an impact on BMI. The results need to be investigated with larger cases.

Keywords: Hemodialysis, H. pylori infection, Body Mass Index

Implication for health policy/practice/research/medical education:

In dialysis patients, chronic infections have been associated with cachexia and anorexia. To determine the association between Helicobacter pylori (HP) infection and body mass index (BMI) in hemodialysis (HD) patients, this study was conducted on 98 HD patients. We found that eradication of HP was accompanied by decrease of BMI, a finding which needs to retest with large sample populations.

Please cite this paper as: Jalalzadeh M, Ghadiani MH, Mousavinasab N. Association between Helicobacter Pylori infection and body mass index, before and after eradication of infection in hemodialysis patients. J Nephropathology. 2012; 1(3): 170-176. DOI: 10.5812/nephropathol.8115

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2906

Your browser does not support the canvas element.


PDF Download: 1222

Your browser does not support the canvas element.

Revision: 30 May 2012
ePublished: 01 Oct 2012
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)