Human leukocyte antigen variation among Iranian renal transplant recipients

Behzad Einollahi; Zohreh Rostami; Mojtaba Teimoori

doi:10.5812/nephropathol.8114

J Nephropathol. 2012;1(3): 164-169.
doi: 10.5812/nephropathol.8114

PMID: 24475410
PMCID: PMC3886157
Scopus ID: 84874909779

Abstract View: 3235

PDF Download: 1525

Original Article

Human leukocyte antigen variation among Iranian renal transplant recipients

Behzad Einollahi ¹, Zohreh Rostami ¹^*, Mojtaba Teimoori ¹

¹ Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

*Corresponding Author: *Corresponding author: Dr. Zohreh Rostami. Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Tel: +982181262073, Fax: +982188067114, , Email: rostami@numonthly.com

Abstract

Background: HLA typing analysis is important in renal transplant patients.

Objectives: We made a plan to determine the most frequent HLA antigens in Iranian kidney transplant patients.

Patients and Methods: In a retrospective cross sectional study, HLA patterns were defined in 512 kidney transplant recipients (67% male and 33% female) from different transplant centers of Tehran, Iran between 2008 and 2011 by microcytotoxicity assay.

Results: The studies samples were of different ethnic groups of the Iranian kidney transplants. Considerable variations were observed in each HLA sub class. A2, A1, A3, A24 and A26 were the most frequent HLA-A antigens. Among HLA-B, the predominant antigens were B35; B13, B15, B13 and B18. The most frequent HLA-DR antigens were DR 4, DR11, DR1, DR3 and DR15. DQ1 showed the highest frequency and followed by DQ3 and DQ2.

Conclusions: These results showed considerable heterogeneity in both HLA class I and class II antigens, which reflects recent admixture of this group with neighboring Middle East populations.

Keywords: HLA typing, Prevalence, Iranian kidneys transplant patients

Implication for health policy/practice/research/medical education:

In a retrospective cross sectional study, HLA typing was defined in 512 kidney transplant recipients, 67% of them were male, and 33% were female, from different transplant center of Tehran, Iran between 2008 and 2011. The results suggest that both class I and class II polymorphisms of the study subjects depict considerable heterogeneity, which reflects recent admixture of this group with neighboring middle east populations.

Please cite this paper as: Einollahi B, Rostami Z, Teimoori M. Human leukocyte antigen variation among Iranian renal transplant recipients . J Nephropathology. 2012; 1(3): 164-169.DOI: 10.5812/nephropathol.8114

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Abstract View: 3236

years	Jan	Feb	Mar	Apr	May	Jun	Jul	Aug	Sep	Oct	Nov	Dec
2024	16	17	11	16	13	13	21	38	26
2023	51	35	40	24	1	32	24	25	19	26	19	12
2022	27	42	48	29	22	36	26	22	24	28	32	37
2021	29	38	28	33	36	32	30	37	36	38	33	30
2020	62	19	47	45	55	30	56	36	42	40	22	30
2019	48	36	31	44	32	21	28	35	36	35	13	43
2018	59	76	79	54	38	43	26	37	41	47	40	34
2017		2	58	48	39	33	39	62	70	48	60	65

PDF Download: 1525

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2024	3	9	12	11	5	9	6	4	11
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2018	30	29	36	23	19	26	14	9	14	19	15	15
2017			19	19	16	20	15	29	33	18	15	24