Treatment of renal manifestations of ANCA-associated vasculitis

Kresimir Galesic; Danica Ljubanovic; Ivica Horvatic

doi:10.5812/nephropathol.8971

J Nephropathol. 2013;2(1): 6-19.
doi: 10.5812/nephropathol.8971

PMID: 24475421
PMCID: PMC3886180
Scopus ID: 84877087218

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Review Article

Treatment of renal manifestations of ANCA-associated vasculitis

Kresimir Galesic^*, Danica Ljubanovic, Ivica Horvatic

*Corresponding Author: Email: kresog@kbd.hr

Abstract

Context: Vasculitis is a clinicopathological entity characterized by inflammation and necrosis of blood vessels.

Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.

Results: Two major autoantigens for ANCA are myeloperoxidase (MPO) and proteinase 3 (PR3), which are proteins in the primary granules of neutrophils and in the lysosomes of monocytes. They are expressed in mature neutrophils of patients with ANCA, while absent in healthy subjects.

Conclusions: The kidney is the most commonly affected vital organ in ANCA-associated vasculitis, and patient outcomes are largely determined by the severity of renal disease at diagnosis and by its response to treatment.

Keywords: Vasculitis, Antineutrophil cytoplasmatic autoantibody, Crescentic glomerulonephritis, Chapel Hill Consensus Conference classification, ANCA-associated small-vessel vasculitis

Implication for health policy/practice/research/medical education:

Vasculitis is a clinicopathological entity characterized by inflammation and necrosis of blood vessels. Antineutrophil cytoplasmatic autoantibodies (ANCA) are associated with a group of necrotizing small vessel vasculitides that have a paucity of vascular deposition of immunoglobulin and complement. The kidney is the most commonly affected vital organ in ANCA-associated vasculitis, and patient outcomes are largely determined by the severity of renal disease at diagnosis and by its response to treatment.

Please cite this paper as: Galesic K, Ljubanovic D, Horvatic I. Treatment of renal manifestations of ANCAassociated Vasculitis. J Nephropathology. 2013; 2(1): 6-19. DOI: 10.5812/nephropathol.8971

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