Lipoprotein (a): More than a bystander in the etiology of hypertension? A study on essential hypertensive patients not yet on treatment

Ali Ghorbani; Mahmoud Rafieian-Kopaei; Hamid Nasri

doi:10.5812/nephropathol.9092

J Nephropathol. 2013;2(1): 67-70.
doi: 10.5812/nephropathol.9092

PMID: 24475427
PMCID: PMC3886175
Scopus ID: 84874738344

Abstract View: 3825

PDF Download: 1820

Brief Report

Lipoprotein (a): More than a bystander in the etiology of hypertension? A study on essential hypertensive patients not yet on treatment

Ali Ghorbani, Mahmoud Rafieian-Kopaei^*, Hamid Nasri

*Corresponding Author: Email: rafieian@yahoo.com

Abstract

Background: Hypertension (HTN) is a very common disorder with a substantial impact on public health because of its complications.

Objectives: To study the association of serum lipoprotein(a) [Lp(a)] elevation with essential hypertension (eHTN).

Patients and Methods: This study was conducted on a group of essential hypertensive patients. Laboratory exams consisting of serum creatinine and Lp(a) were measured.

Results: Ninety five essential hypertensive patients were enrolled to the study. Serum LP (a) in patients was 46.5±20. In patients an inverse correlation between serum Lp(a) andcreatinine clearance was seen (r = -0.175 p<0.05). There was a significant correlation between serum Lp(a) and age (r =0.191 p<0.05) or duration of HTN (known duration of hypertension period) (r =0.362 p<0.05).

Conclusions: Our data suggest that Lp(a) may be involved as a cofactor in essential hypertension, with a mechanism that remains to be elucidated.

Keywords: Essential hypertension, Lipoprotein (a), Renal failure

Implication for health policy/practice/research/medical education:

Lipoprotein (a) may be involved as a cofactor in essential hypertension, with a mechanism that remains to be elucidated.

Please cite this paper as: Ghorbani A, Rafieian-Kopaei M, Nasri H. Lipoprotein (a): More than a bystander in the etiology of hypertension? A study on essential hypertensive patients not yet on treatment. J Nephropathology. 2013; 2(1): 67-70. DOI: 10.5812/nephropathol. 9092

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