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J Nephropathol. 2013;2(2): 129-134.
doi: 10.12860/JNP.2013.21
PMID: 24475439
PMCID: PMC3891148
Scopus ID: 84878602547
  Abstract View: 2676
  PDF Download: 1416

Original Article

Protective effect of selenium on cisplatin induced nephrotoxicity: A double-blind controlled randomized clinical trial

Ali Ghorbani 1 * , Bita Omidvar 2, Abazar Parsi 3
*Corresponding author: Dr. Ali Ghorbani, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Tel/Fax: +986113743013. dralighorbani@yahoo.com

Abstract

Background: Renal injury is common following cisplatin infusion. Some agents have been used to attenuate cisplatin nephrotoxicity. However, except hydration, none of them has been proved to be effective.

Objective: In this study selenium as an antioxidant supplement was tested on cisplatin induced renal injury.

Patients and Methods: 122 cancerous patients (85 male and 37 female; age range of 14 to 82 years old) were enrolled to receive chemotherapy regimens consisting cisplatin. They were allocated into two groups using a random number list . Investigators, patients and analyzers all, were blinded in allocation by using sealed opaque envelopes. Intervention group received a single 400 mcg selenium tablet and patients in control group took a placebo tablet which was similar with selenium preparation in color, weight, shape and taste. Primary end points were an increase in plasma creatinine above 1.5 mg/dl in men and 1.4mg/dl in women, or increase of plasma creatinine more than 50% from baseline or urine flow rate less than 0.5 ml/kg/h. Creatinine level was measured initially and on the 5th day after cisplatin therapy.

Results: There was no difference in cumulative dose of cisplatin between the groups (p=0.54). There were not evidences of acute renal failure (ARF) in cases. While, among placebo group, 7 patients had criteria of acute kidney injury.

Conclusions: selenium could probably prevent cisplatin-induced acute kidney injury, when it is added to hydration therapy in cancerous patients.

Keywords: Nephropathy, Cisplatin, Selenium, Renal failure

Implication for health policy/practice/research/medical education:

Renal injury is common following cisplatin infusion. Selenium could probably prevent cisplatin-induced acute renal failure when it is added to hydration in cancerous patients.

Please cite this paper as: Ghorbani A, Omidvar B, Parsi A. Protective effect of selenium on cisplatin induced nephrotoxicity: A double-blind controlled randomized clinical trial. J Nephropathology. 2013; 2(2): 129-134. DOI: 10.12860/JNP.2013.21

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Revision: 28 Dec 2012
ePublished: 01 Apr 2013
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