J Nephropathol. 2013;2(4): 214-216.
doi: 10.12860/JNP.2013.35
PMID: 24475453
PMCID: PMC3891127
Scopus ID: 84881124187
  Abstract View: 2362
  PDF Download: 1425


Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies

Ali Nayer 1*, Arif Asif 2
*Corresponding Author: *Corresponding author:Ali Nayer, MD, Division of Nephrology and Hypertension, University of Miami, Clinical Research Building, Suite 825, 1120 NW 14th Street, Miami, FL 33136, USA. Tel: 305.243.8491, Fax: 305.243.3506,, Email: ANayer@med.miami.edu

Implication for health policy/practice/research/medical education:

Membranous nephropathy (MN) is a glomerular disease due to subepithelial immune deposits and local complement activation resulting in podocyte injury and proteinuria. Patients with idiopathic (but not secondary) MN had circulating autoantibodies, predominantly of the IgG4 subclass, directed against M-type phospholipase A2 receptor (PLA2R) located on podocytes. It is also possible that the binding of anti-PLA2R antibodies to PLA2R on podocytes could alter receptor function resulting in podocyte dysfunction.

Please cite this paper as: Nayer A, Asif A. Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies. J Nephropathology. 2013; 2(4): 214- 216, DOI: 10.12860/JNP.2013.35

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ePublished: 01 Oct 2013
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