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J Nephropathol. 2013;2(4): 217-233.
doi: 10.12860/JNP.2013.36
PMID: 24475454
PMCID: PMC3891131
Scopus ID: 84894086553
  Abstract View: 3138
  PDF Download: 1790

Review Article

Hepatitis C virus infection in nephrology patients

Lionel Rostaing 1,2,3*, Jacques Izopet 2,3,4, Nassim Kamar 1,2,3
*Corresponding Author: *Corresponding author:Prof. Lionel Rostaing, Department of Nephrology, Dialysis, and Organ Transplantation CHU Rangueil, Toulouse University Hospital.1Avenue J.Poulhès, TSA 50032, 31059 Toulouse Cedex 9, France. Tel: + 33 5 61 32 25 84, Fax: + 33 5 61 32 28 64, , Email: rostaing.l@chu-toulouse.fr

Abstract

Context: Hepatitis C virus (HCV) infection leads to chronic liver disease, but also to extra-hepatic manifestations.

Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.

Results: Herein, we provide an overview of renal diseases related to HCV and their therapies, as well as the treatment options available for HCV (+)/RNA (+) dialysis patients. We will not mention, however, HCV infection-related complications in the post-kidney transplantation setting.

Conclusions: Extra-hepatic manifestations of HCV infection include mixed cryoglobulinemia, lymphoproliferative disorders, and renal disease. HCV infection has been reported in association with distinct histological patterns of glomerulonephritis in native kidneys.


Implication for health policy/practice/research/medical education:

Hepatitis C virus (HCV) infection leads to chronic liver disease, but also to extra-hepatic manifestations. These include mixed cryoglobulinemia, lymphoproliferative disorders, and renal disease. HCV infection has been reported in association with distinct histological patterns of glomerulonephritis in native kidneys . Membranoproliferative glomerulonephritis (MPGN) associated with type II cryoglobulinemia is the predominant type of HCV-related glomerulonephritis.

Please cite this paper as: Rostaing L, Izopet J, Kamar N. Hepatitis C virus infection in nephrology patients. J nephropathology. 2013; 2(4): 217-233, DOI: 10.12860/JNP.2013.36

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ePublished: 01 Jul 2013
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