What nephrolopathologists need to know about antiphospholipid syndrome-associated nephropathy: Is it time for formulating a classification for renal morphologic lesions?

Muhammed Mubarak; Hamid Nasri

doi:10.12860/jnp.2014.02

J Nephropathol. 2014;3(1): 4-8.
doi: 10.12860/jnp.2014.02

PMID: 24644536
PMCID: PMC3956907
Scopus ID: 84893138685

Abstract View: 3359

PDF Download: 1590

Short Review Article

What nephrolopathologists need to know about antiphospholipid syndrome-associated nephropathy: Is it time for formulating a classification for renal morphologic lesions?

Muhammed Mubarak ¹^*, Hamid Nasri ²

¹ Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan
² Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran

*Corresponding Author: Corresponding author: Prof. Muhammed Mubarak, Histopathology Department, Sindh Institute of Urology and Transplantation, Karachi-74200, Pakistan. Email: drmubaraksiut@yahoo.com, Email: drmubaraksiut@yahoo.com

Abstract

Context: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder which commonly affects kidneys.

Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science have been searched.

Results: There is sufficient epidemiological, clinical and histopathological evidence to show that antiphospholipid syndrome is a distinctive lesion caused by antiphospholipid antibodies in patients with different forms of antiphospholipid syndrome. It is now time to devise a classification for an accurate diagnosis and prognostication of the disease.

Conclusions: Now that the morphological lesions of APSN are sufficiently well characterized, it is prime time to devise a classification which is of diagnostic and prognostic utility in this disease.

Keywords: Antiphospholipid syndrome, APS-associated nephropathy, Systemic lupus erythematosus, Thrombotic microangiopathy

Implication for health policy/practice/research/medical education:

There is sufficient epidemiological, clinical and histopathological evidence to show that antiphospholipid syndrome is a distinctive lesion caused by antiphospholipid antibodies in patients with different forms of antiphospholipid syndrome. It is now time to devise a classification for an accurate diagnosis and prognostication of the disease.

Please cite this paper as: Mubarak M, Nasri H.What nephrolopathologists need to know about antiphospholipid syndrome-associated nephropathy: Is it time for formulating a classification for renal morphologic lesions? J Nephropathol. 2014; 3(1): 4-8. DOI: 10.12860/jnp.2014.02

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Abstract View: 3360

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