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J Nephropathol. 2015;4(1): 7-12.
doi: 10.12860/jnp.2015.02
PMID: 25657979
PMCID: PMC4316584
Scopus ID: 84925154815
  Abstract View: 2735
  PDF Download: 1139

Original Article

Epidemiological, clinical and laboratorial profile of renal amyloidosis: a 12-year retrospective study of 37 cases

Elissa Oliveira da Fonseca 1*, Porphirio Jose Soares Filho 1, Licinio Esmeraldo da Silva 1, Maria Lucia Ribeiro Caldas 1

1 Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Rio de Janeiro, Brazil
*Corresponding Author: Corresponding author: Elissa Oliveira da Fonseca, 50 Ataulfo de Paiva Avenue, Leblon, Rio de Janeiro, Brazil., Email: elissafonseca@huap.uff.br

Abstract

Background: Renal amyloidosis is one of the main differential diagnoses in the investigation of nephrotic proteinuria in adults, especially elderly patients.

Objectives: The aim of this article is to contribute to international research with epidemiologic data of renal amyloidosis, given the lack of uniformity described in the literature.

Patients and Methods: A retrospective study of 37 cases of renal amyloidosis diagnosed by kidney biopsy, between 2000 and 2011, considering epidemiological, clinical and laboratory data.

Results: Subjects aged between 32 and 80 years. Of the 37 cases, 21 (56.8%) were diagnosed as non-light chain (non-AL) renal amyloidosis and 16 (43.2%) as light chain amyloidosis (AL). There was seen an increase in number of both AL and non-AL cases, with a slight predominance in non-AL. The mean 24-hour proteinuria was 5839.0 mg/day. Hematuria was present in 75% of patients. Hypertension was reported in 34% of patients. Acute renal failure, occurred in about 10% of patients, and chronic loss of renal function was present in about 5% at diagnosis.

Conclusions: Renal amyloidosis is a disease of increasing incidence. The forms of clinical presentation proved to be variable, but the presence of proteinuria or nephrotic syndrome in elderly patients should always prompt the suspicion of renal amyloidosis and is a formal indication of renal biopsy.


Implication for health policy/practice/research/medical education:

Renal amyloidosis is a disease of increasing incidence. The forms of clinical presentation proved to be variable, but the presence of proteinuria or nephrotic syndrome in elderly patients should always prompt the suspicion of renal amyloidosis and is a formal indication of renal biopsy.

Please cite this paper as: Fonseca EO, Soares Filho PJ, Silva LE, Caldas MLR. Epidemiological, clinical and laboratorial profile of renal amyloidosis: a 12-year retrospective study of 37 cases. J Nephropathol. 2015; 4(1):7-12. DOI: 10.12860/jnp.2015.02

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ePublished: 01 Jan 2015
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