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J Nephropathol. 2015;4(1): 13-17.
doi: 10.12860/jnp.2015.03
PMID: 25657980
PMCID: PMC4316580
Scopus ID: 84925071442
  Abstract View: 3337
  PDF Download: 1270

Original Article

A randomized pilot trial on the effect of granulocyte-colony stimulating factor on antibody response in hemodialysis patients who had not responded to routine hepatitis B virus vaccine

Jamshid Roozbeh 1,2, Kamran Bagheri-Lankarani 3, Poopak Mohaghegh 2, Ghanbarali Raeesjalali 2, Saeed Behzadi 2, Mehdi Sagheb 2, Mehrdad Vossoughi 4, Bahar Bastani 5*

1 Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3 Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Dental Public Health, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
5 Division of Nephrology, Saint Louis University, School of Medicine, Saint Louis, Missouri, USA
*Corresponding Author: Corresponding author: Prof. Bahar Bastani, Division of Nephrology, Saint Louis University Health Sciences Center, Saint Louis, Missouri, USA., Email: bastanib@slu.edu

Abstract

Background: Various strategies have been applied to improve the response to hepatitis B virus (HBV) vaccination in hemodialysis patients.

Objectives: The present study was under taken to compare the seroconversion rate of hemodialysis patients who had not respond to 3 intramuscular (IM) doses (40 μg each) of HBV vaccine , after a fourth IM dose (40 μg) of HBV vaccine that was administered alone or with subcutaneous granulocyte-colony stimulating factor (G-CSF) (5 μg/kg).

Patients and Methods: Twenty six hemodialysis patients who had not responded to 3 IM injections of HBV vaccine were randomized into 2 groups: Group 1 received a booster dose of 40 μg HBV vaccine IM, group 2 received a booster dose of 40 μg HBV vaccine IM plus 5 μg/kg subcutaneous G-CSF. Antibody to hepatitis B surface antigen was measured 1 month after the booster dose.

Results: Seroconversion rate in group 1 was 40%. There was a trend towards a higher seroconversion rate at 60% in group 2 patients; however, because of the small number of patients it did not reach statistical significance.

Conclusions: Larger number of patients and other innovative strategies should be applied for vaccination of this group of patients. More prolonged follow up of the patients is needed to evaluate the duration of protection induced by each method of vaccination.


Implication for health policy/practice/research/medical education:

This study was performed on 26 hemodialysis patients who had not responded to three intramuscular (IM) injections of hepatitis B virus (HBV) vaccine. The patients were divided into two groups: Group 1 received a booster dose of 40 μg HBV vaccine IM, group 2 received a booster dose of 40 μg HBV vaccine IM plus 5 μg/kg subcutaneous granulocyte-colony stimulating factor (G-CSF). There was a trend towards a higher seroconversion rate (60% vs 40%) in group 2 compared to group 1 patients, however, because of the small number of patients it did not reach statistical significance. Larger number of patients should be applied to better find the impact of G-CSF treatment on intensification of seroconversion rate in hemodialysis patients.

Please cite this paper as: Roozbeh J, Bagheri-Lankarani K, Mohaghegh P, Raeesjalali G, Behzadi S, Sagheb M, et al. A randomized pilot trial on the effect of granulocyte-colony stimulating factor on antibody response in hemodialysis patients who had not responded to routine hepatitis B virus vaccine. J Nephropathol. 2015; 4(1):13-17. DOI: 10.12860/jnp.2015.03

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ePublished: 01 Jan 2015
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