Abstract
Background: Prostate-specific antigen (PSA) is a serine protease that is secreted by prostate
cells and it is useful as a tumor marker for prostate cancer.
Objectives: In this study, the relationship between some of metabolic factors and serum PSA
level was investigated.
Patients and Methods: In this cross-sectional study, patients with urinary symptoms or for
screening of the prostate cancer (after 50 years of age or 40 years with a family history of
prostate cancer), were evaluated. Collected data included metabolic syndrome factors such
as cholesterol (Chol), triglycerides (TG), fasting blood sugar (FBS), and body mass index
(BMI), serum PSA level, prostate volume and age.
Results: 481 patients were enrolled to this study with the average age of 60.69 ± 9.72 years
and the average PSA level of 1.70 ng/ml. Data analysis showed that there was a significant
relationship between serum PSA level with age (P < 0.001, r = 0.30) and prostate volume
(P < 0.001, r = 0.29). There were not significant relationship between serum PSA level with
TG (P = 0.57, r = 0.026), Chol (P = 0.57, r = -0.025), FBS (P = 0.054, r = 0.088), and BMI
(P = 0.89, r = 0.006).
Conclusions: This study showed that, with increasing age and prostate volume, serum PSA
level increased, and an increase in the levels of cholesterol, TG, FBS and BMI did not have
significant effect on serum PSA level.