J Nephropathol. 2017;6(1): 10-14.
doi: 10.15171/jnp.2017.03
PMID: 28042548
PMCID: PMC5106877
Scopus ID: 84992358064
  Abstract View: 19178
  PDF Download: 2917

Original Article

Impact of vitamin D therapy on decreasing of proteinuria in type 2 diabetic patients

Ali Momeni 1, Mahmood Mirhosseini 1, Mohsen Kabiri 1*, Soleiman Kheiri 2

1 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Social Health Determinants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: *Corresponding author: Mohsen Kabiri, Internal Medicine Department, Shahrekord University of Medical Sciences. Shahrekord, Iran., Email: drmkabiriq@gmail.com


Background: Vitamin D (Vit D) deficiency is a common disorder in diabetic patients and may be a risk factor for ischemic heart disease and exacerbation of diabetic nephropathy(DN).

Objectives: The aim of this study was to evaluate the effect of Vit D3 therapy on protein uriain type 2 diabetic patients with deficient or insufficient serum Vit D.

Patients and Methods: In a double blind clinical trial, 60 type 2 diabetic patients with proteinuria greater than 150 mg/day who had Vit D deficiency or insufficiency were randomly enrolled in two equal groups. Pearl of Vit D as 50 000 IU/week and placebo (1 tablet per week) were prescribed in patients of case and control groups respectively for 8 weeks. At the beginning and 2 months later, 24 hours urine protein was checked in all patients.

Results: There is no difference between serums Vit D level in case and control group at the beginning of the study, however at the end of the study serum Vit D level was significantly higher in the case group. There is no difference in proteinuria between case and control group at the beginning and the end of the study, while a significant difference between the changes of proteinuria before and after the study was seen in two groups (P = 0.028).

Conclusions: Vit D deficiency may exacerbate protein uric and DN, hence correction of Vit D deficiency may decrease proteinuria in diabetic patients with nephropathy.

Implication for health policy/practice/research/medical education:

Nephropathy is a common complication of diabetes, so management of it could lead to decreasing of mortality and morbidity of the patients. In addition of angiotensin converting enzyme inhibitors and angiotensin receptor blockers, other drugs such as spironolactone, statins, and allopurinol were used for management of diabetic nephropathy with acceptable results in some studies. Vitamin D metabolites may have renoprotective and anti-proteinuric effect, decreasing of insulin resistance and blood pressure lowering effect, as well. Pearl of vitamin D is an inexpensive, safe and probably effective drug for patients with diabetic nephropathy and vitamin D deficiency.

Please cite this paper as: Momeni A, Mirhosseini M, Kabiri M, Kheiri S. Effect of vitamin D on proteinuria in type 2 diabetic patients. J Nephropathol. 2017;6(1):10-14. DOI: 10.15171/jnp.2017.03.

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ePublished: 14 Aug 2016
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