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J Nephropathol. 2017;6(1): 15-24.
doi: 10.15171/jnp.2017.04
PMID: 28042549
PMCID: PMC5106878
Scopus ID: 84992411186
  Abstract View: 3833
  PDF Download: 1918

Original Article

Relationship between IL-17 and ambulatory blood pressure inpolycystic ovary syndrome

Fatemeh Foroozanfard 1, Alireza Soleimani 2, Elham Arbab 1, Mansooreh Samimi 1, Mohammad Reza Tamadon 3*

1 Department of Gynecology and Obstetrics, Kashan University of Medical Sciences, Kashan, Iran
2 Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran
3 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran
*Corresponding Author: *Corresponding author: Mohammad Reza Tamadon, Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran. , Email: mrt_tamadon@yahoo.com

Abstract

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders with an inflammatory basis. It is associated with hyperandrogenism in women and can be also associated with increased activity of the renin-angiotensin system (RAS). Approximately 5% to 10% of women of reproductive age are affected by this disease. This syndrome is the main cause of infertility. Blood pressure may be one of the complications of the syndrome.

Objectives: In this study, we sought to assess the role of the IL-17 inflammatory cytokine in increasing blood pressure in patients with PCOS.

Patients and Methods: In this cross-sectional study, after obtaining informed consent, we evaluated 85 patients with PCOS. IL-17 serum level was measured after separating the serum via ELISA method. The results obtained for the two groups of patients with high blood pressure and normal blood pressure were compared with each other.

Results: The daytime blood pressure was abnormal in eight patients, while it was normal in 72 patients. The blood pressure during the day had a direct correlation with the IL-17serum level; as a result, the mean IL-17 serum level in patients with high blood pressure was 77.10 ± 17.94 ??? g/ml while in those with normal blood pressure it was 55.20 ± 13.71 ??? g/ml (P = 0.001). High blood pressure during the night also showed a direct relation with theIL-17 serum level (P = 0.001). In addition, increasing of ambulatory 24-hourblood pressure was significantly related with IL-17 serum level, in such a way that the IL-17 serum level of people with high blood pressure rose by almost 22 ???g/ml during 24 hours (P = 0.001).

Conclusions: Our results showed an association between PCO syndrome and inflammatory factors. The IL-17 serum level was directly associated with the increase in blood pressure.


Implication for health policy/practice/research/medical education:

This study has implication for the researcher as well as practitioners, gynecologist and internist.

Please cite this paper as:  Foroozanfard F, Soleimani A, Arbab E, Samimi M, Tamadon MR. Relationship between  IL-17 and ambulatory blood pressure inpolycystic ovary syndrome. J Nephropathol. 2017;6(1):15-23. DOI: 10.15171/jnp.2017.04.

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ePublished: 08 Aug 2016
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