Multifaceted role of apolipoprotein L1 risk variants and nephropathy

Mohsen Akhavan Sepahi; Bahram Niknafs

doi:10.15171/jnp.2020.03

J Nephropathol. 2020;9(1): e03.
doi: 10.15171/jnp.2020.03

Scopus ID: 85078296609

Abstract View: 2239

PDF Download: 1051

Epidemiology and Prevention

Multifaceted role of apolipoprotein L1 risk variants and nephropathy

Mohsen Akhavan Sepahi ¹ , Bahram Niknafs ²^*

¹ Department of Pediatric Nephrology, School of Medicine, Qom University of Medical Sciences, Qom, Iran
² Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

*Corresponding Author: *Corresponding author: Bahram Niknafs, Email: , Email: bahraminik@gmail.com

Keywords: Apolipoprotein L-1, Chronic kidney disease, HIV-associated nephropathy, Membranous nephropathy, Sickle-cell nephropathy, Hypertensive nephropathy, Arterionephrosclerosis, Lupus nephritis, End-stage renal disease

Implication for health policy/practice/research/medical education:

APOL1 protein is encoded by the APOL1 gene in humans and plays a role in innate immunity. The spectrum of APOL1-related nephropathies consists of HIV-associated nephropathy (HIVAN), segmental glomerulosclerosis (FSGS), membranous nephropathy (MGN), sickle-cell nephropathy, hypertensive nephropathy, arterionephrosclerosis, lupus nephritis, microalbuminuria, chronic kidney disease and end-stage renal disease. Moreover, APOL1 nephropathy risk variants are associated with shorter survival of deceased kidney allografts, lower renal function, interstitial and fibrosis glomerulosclerosis.

Please cite this paper as: Akhavan Sepahi, Niknafs B. Multifaceted role of apolipoprotein L1 risk variants and nephropathy. J Nephropathol. 2020;9(1):e03. DOI: 10.15171/jnp.2020.03.