J Nephropathol. 2020;9(3): e30.
doi: 10.34172/jnp.2020.30

Scopus ID: 85084632616
  Abstract View: 1334
  PDF Download: 894

Case Report

Rapid progressive anti-GBM glomerulonephritis with multiple auto-antibodies

David Micarelli 1* ORCID logo, Teresa Valentina Ranalli 2 ORCID logo, Anna Rita Taddei 3 ORCID logo, Angela Solazzo 4 ORCID logo, Francesca Moccia 1 ORCID logo, Sandro Feriozzi 1 ORCID logo

1 Nephrology and Dialysis Unit, Belcolle Hospital, Viterbo, Italy
2 Division of Surgical Pathology, Belcolle Hospital, Viterbo, Italy
3 Center of Large Equipments, Section of Electron Microscopy, University of Tuscia, Viterbo, Italy
4 Nephrology and Dialysis Unit, Policlinico dei Castelli, ASL Roma 6, Italy
*Corresponding Author: Email: davidmicarelli@gmail.com


Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by progressive loss of renal function in a short period. At renal biopsy, it is characterized by crescent formation. RPGN may be associated with the presence of circulating antibodies. We report a case of type IV RPGN [ANCA and Anti–glomerular basement membrane (anti-GBM) antibody disease], a severe disease causing a difficult to treat picture. Our case was complicated by severe thrombocytopenia due to the use of heparin and later on by thrombotic microangiopathy. These events occurred rapidly, making the clinical framing and management decisions very hard.

Implication for health policy/practice/research/medical education:

We report a case with the contemporaneous presence of multiple auto-antibodies (anti-GBM, ANCA, ANA, anti-PF4) and a clinical feature of rapidly progressive glomerulonephritis.

Please cite this paper as: Micarelli D, Ranalli TV, Taddei AR, Solazzo A , Moccia F, Feriozzi S. Rapid progressive anti-GBM glomerulonephritis with multiple auto-antibodies. J Nephropathol. 2020;9(3):e30. DOI: 10.34172/jnp.2020.30.

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Submitted: 02 Feb 2020
Accepted: 01 Mar 2020
ePublished: 06 Mar 2020
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