David Micarelli
1* 
, Teresa Valentina Ranalli
2 , Anna Rita Taddei
3 , Angela Solazzo
4 , Francesca Moccia
1 , Sandro Feriozzi
1 1 Nephrology and Dialysis Unit, Belcolle Hospital, Viterbo, Italy
2 Division of Surgical Pathology, Belcolle Hospital, Viterbo, Italy
3 Center of Large Equipments, Section of Electron Microscopy, University of Tuscia, Viterbo, Italy
4 Nephrology and Dialysis Unit, Policlinico dei Castelli, ASL Roma 6, Italy
Abstract
Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by progressive loss of renal function in a short period. At renal biopsy, it is characterized by crescent formation. RPGN may be associated with the presence of circulating antibodies. We report a case of type IV RPGN [ANCA and Anti–glomerular basement membrane (anti-GBM) antibody disease], a severe disease causing a difficult to treat picture. Our case was complicated by severe thrombocytopenia due to the use of heparin and later on by thrombotic microangiopathy. These events occurred rapidly, making the clinical framing and management decisions very hard.
Implication for health policy/practice/research/medical education:
We report a case with the contemporaneous presence of multiple auto-antibodies (anti-GBM, ANCA, ANA, anti-PF4) and a clinical feature of rapidly progressive glomerulonephritis.
Please cite this paper as: Micarelli D, Ranalli TV, Taddei AR, Solazzo A , Moccia F, Feriozzi S. Rapid progressive anti-GBM glomerulonephritis with multiple auto-antibodies. J Nephropathol. 2020;9(3):e30. DOI: 10.34172/jnp.2020.30.