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J Nephropathol. 2021;10(4): e39.
doi: 10.34172/jnp.2021.39
  Abstract View: 324
  PDF Download: 87

Original Article

Beneficial effects of Terminalia phillyreifolia (Van Heurck & Müll.Arg.) Gere & Boatwr. bark extract in streptozotocin induced hyperglycaemia and diabetic nephropathy in rats

Archana Navale 1 * ORCID logo, Devanshu Patel 2, Archana Paranjape 3

1 Department of Pharmacology, Parul Institute of Pharmacy, Parul University, Post. Limda, Ta. Waghodia, Dist.Vadodara-391760. Gujarat, India
2 Department of Pharmacology, Parul Institute of Medical Science and Research, Parul University, Post. Limda, Ta. Waghodia, Dist. Vadodara-391760. Gujarat, India
3 Director, Edutech Learning Solutions Pvt. Ltd., Vadodara, Gujarat, India

Abstract

Introduction: Renal damage is a common clinical manifestation in diabetic patients. Therefore, nephroprotective effect is a desirable property for an antidiabetic agent. Natural compounds belonging to Terminalia phillyreifolia (TP) owing to their potent antioxidant and anti-inflammatory activity may prove to be such agents.

Objectives: The objectives of the present study were to evaluate methanolic extract of TP bark for its antihyperglycemic, antioxidant and nephroprotective effect in streptozotocin (STZ) induced diabetes mellitus and nephropathy in rats.

Materials and Methods: Diabetic male Wistar rats were divided into five groups; namely, normal control, disease control, standard (NPH insulin, subcutaneously), BE100 (bark extract 100 mg/kg, p.o.) and BE300 (bark extract 300 mg/kg, orally). Treatment was continued for 8 weeks. Plasma glucose levels, oxidative stress parameters, serum creatinine levels, blood urea nitrogen (BUN) levels, per day urine output, urinary protein excretion (UPE) and kidney hypertrophy index were determined at appropriate time points.

Results: Untreated animals developed severe hyperglycemia and major disturbance in renal function. Rats in standard and BE treated groups had significantly lower plasma glucose levels and oxidative stress markers as compared to disease control animals. BE rats also exhibited nearly normal urine volumes indicating better glomerular filtration rate. They had lower urinary protein, serum creatinine, BUN levels and lower renal hypertrophy index as compared to untreated animals.

Conclusion: TP Bark extract corrected the hyperglycaemia and exerted protective effect against diabetes induced renal damage in rats, which may be partly due to its anti-oxidant effect. Therefore, TP extract can be further evaluated as potential antidiabetic therapy

Keywords: Diabetic renal damage, Nephropathy, Anogeissus pendula, Proteinuria, Anti-oxidant, Serum creatinine, Terminalia phillyreifolia

Implication for health policy/practice/research/medical education: This study provides a scientific basis for the age-old use of the plant Terminalia phillyreifolia. In this study we evaluated its effect on animal model of diabetic nephropathy. Untreated diabetic animals in this study developed renal damage associated with diabetes mellitus, while animals which were treated with T. phillyreifolia extract, demonstrated lower blood glucose levels and preserved kidney function. Thus, our study demonstrated the antidiabetic and nephroprotective effect of T. phillyreifolia. The plant extract can be further studied for identification and isolation of active constituent that is responsible for its beneficial effect. It can be the next successful anti-diabetic agent from plant origin subject to scientific findings.

Please cite this paper as: Navale A, Patel D, Paranjape A. Beneficial effects of Terminalia phillyreifolia (Van Heurck & Müll.Arg.) Gere & Boatwr. bark extract in streptozotocin induced hyperglycaemia and diabetic nephropathy in rats. J Nephropathol. 2021;10(4):e39. DOI: 10.34172/jnp.2021.39.

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Submitted: 17 Jul 2020
Accepted: 15 Jan 2021
ePublished: 16 Feb 2021
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